Homo sapiens Gene: NUP214
Summary
InnateDB Gene IDBG-89810.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NUP214
Gene Name nucleoporin 214kDa
Synonyms CAIN; CAN; D9S46E; N214; p250;
Species Homo sapiens
Ensembl Gene ENSG00000126883
Encoded Proteins
nucleoporin 214kDa
nucleoporin 214kDa
nucleoporin 214kDa
nucleoporin 214kDa
nucleoporin 214kDa
nucleoporin 214kDa
nucleoporin 214kDa
nucleoporin 214kDa
nucleoporin 214kDa
nucleoporin 214kDa
nucleoporin 214kDa
nucleoporin 214kDa
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
NUP214 and NUP153 are nucleoporins that control the nucleo-cytoplasmic shuttling and, along with XPO1-dependent nuclear export, the subcellular distribution of latent STAT1.
Entrez Gene
Summary The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. This gene is a member of the FG-repeat-containing nucleoporins. The protein encoded by this gene is localized to the cytoplasmic face of the nuclear pore complex where it is required for proper cell cycle progression and nucleocytoplasmic transport. The 3' portion of this gene forms a fusion gene with the DEK gene on chromosome 6 in a t(6,9) translocation associated with acute myeloid leukemia and myelodysplastic syndrome. [provided by RefSeq, Jul 2008]
The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. This gene is a member of the FG-repeat-containing nucleoporins. The protein encoded by this gene is localized to the cytoplasmic face of the nuclear pore complex where it is required for proper cell cycle progression and nucleocytoplasmic transport. The 3\' portion of this gene forms a fusion gene with the DEK gene on chromosome 6 in a t(6,9) translocation associated with acute myeloid leukemia and myelodysplastic syndrome. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:131125561-131234670
Strand Forward strand
Band q34.13
Transcripts
ENST00000359428 ENSP00000352400
ENST00000451030 ENSP00000405014
ENST00000411637 ENSP00000396576
ENST00000453861 ENSP00000416934
ENST00000483497 ENSP00000436793
ENST00000489260
ENST00000470765
ENST00000465486
ENST00000498010 ENSP00000435583
ENST00000476004 ENSP00000433606
ENST00000496921
ENST00000531584 ENSP00000435874
ENST00000526412
ENST00000525561
ENST00000530843
ENST00000530863 ENSP00000434223
ENST00000525980
ENST00000530630
ENST00000526346 ENSP00000437139
ENST00000531929
ENST00000524578
ENST00000531600 ENSP00000435364
ENST00000528114
ENST00000525384
ENST00000529286
ENST00000530491
ENST00000528406 ENSP00000433654
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 57 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 57 [view]
Protein-Protein 57 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005215 transporter activity
GO:0005487 nucleocytoplasmic transporter activity
GO:0005515 protein binding
Biological Process
GO:0000278 mitotic cell cycle
GO:0005975 carbohydrate metabolic process
GO:0006406 mRNA export from nucleus
GO:0006606 protein import into nucleus
GO:0006611 protein export from nucleus
GO:0007077 mitotic nuclear envelope disassembly
GO:0008645 hexose transport
GO:0010467 gene expression
GO:0010827 regulation of glucose transport
GO:0015758 glucose transport
GO:0016032 viral process
GO:0016070 RNA metabolic process
GO:0016071 mRNA metabolic process
GO:0019221 cytokine-mediated signaling pathway
GO:0044281 small molecule metabolic process
GO:0045087 innate immune response (InnateDB)
GO:0051726 regulation of cell cycle
GO:0055085 transmembrane transport
Cellular Component
GO:0005634 nucleus
GO:0005643 nuclear pore
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0005925 focal adhesion
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
TGF_beta_Receptor pathway
REACTOME
Transmembrane transport of small molecules pathway
Influenza Infection pathway
Interactions of Vpr with host cellular proteins pathway
Vpr-mediated nuclear import of PICs pathway
Myoclonic epilepsy of Lafora pathway
Antiviral mechanism by IFN-stimulated genes pathway
Glucose transport pathway
Hexose transport pathway
Cytokine Signaling in Immune system pathway
Metabolism of carbohydrates pathway
Late Phase of HIV Life Cycle pathway
Viral Messenger RNA Synthesis pathway
Transcriptional regulation by small RNAs pathway
Nuclear Pore Complex (NPC) Disassembly pathway
HuR stabilizes mRNA pathway
Influenza Viral RNA Transcription and Replication pathway
Interferon Signaling pathway
Cell Cycle pathway
Immune System pathway
Regulation of Glucokinase by Glucokinase Regulatory Protein pathway
M Phase pathway
HIV Life Cycle pathway
Mitotic Prophase pathway
Regulation of mRNA stability by proteins that bind AU-rich elements pathway
Rev-mediated nuclear export of HIV RNA pathway
Cell Cycle, Mitotic pathway
HIV Infection pathway
ISG15 antiviral mechanism pathway
Influenza Life Cycle pathway
Nuclear import of Rev protein pathway
Metabolism pathway
Host Interactions of HIV factors pathway
SLC-mediated transmembrane transport pathway
Interactions of Rev with host cellular proteins pathway
Gene Expression pathway
Nuclear Envelope Breakdown pathway
Disease pathway
Glycogen storage diseases pathway
Regulatory RNA pathways pathway
KEGG
RNA transport pathway
INOH
PID BIOCARTA
Sumoylation by ranbp2 regulates transcriptional repression [Biocarta view]
Mechanism of protein import into the nucleus [Biocarta view]
Cycling of ran in nucleocytoplasmic transport [Biocarta view]
PID NCI
BMP receptor signaling
Role of Calcineurin-dependent NFAT signaling in lymphocytes
Regulation of cytoplasmic and nuclear SMAD2/3 signaling
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.654530 Hs.671104
RefSeq NM_005085 XM_005272216 XM_005272217 XM_006717292
HUGO
OMIM
CCDS CCDS6940
HPRD 00258
IMGT
EMBL
GenPept
RNA Seq Atlas