InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: NPPB

Summary

InnateDB Gene

IDBG-89897.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NPPB

Gene Name

natriuretic peptide B

Synonyms

BNP

Species

Homo sapiens

Ensembl Gene

ENSG00000120937

Encoded Proteins

IDBP-89899

natriuretic peptide B

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene is a member of the natriuretic peptide family and encodes a secreted protein which functions as a cardiac hormone. The protein undergoes two cleavage events, one within the cell and a second after secretion into the blood. The protein's biological actions include natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and a key role in cardiovascular homeostasis. A high concentration of this protein in the bloodstream is indicative of heart failure. Mutations in this gene have been associated with postmenopausal osteoporosis. [provided by RefSeq, Jul 2008]
This gene is a member of the natriuretic peptide family and encodes a secreted protein which functions as a cardiac hormone. The protein undergoes two cleavage events, one within the cell and a second after secretion into the blood. The protein\'s biological actions include natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and a key role in cardiovascular homeostasis. A high concentration of this protein in the bloodstream is indicative of heart failure. Mutations in this gene have been associated with postmenopausal osteoporosis. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:11857464-11858931

Strand

Reverse strand

Band

p36.22

Transcripts

ENST00000376468

ENSP00000365651

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005179	hormone activity
GO:0008613	diuretic hormone activity

Biological Process

GO:0006182	cGMP biosynthetic process
GO:0007166	cell surface receptor signaling pathway
GO:0007168	receptor guanylyl cyclase signaling pathway
GO:0007589	body fluid secretion
GO:0008217	regulation of blood pressure
GO:0016525	negative regulation of angiogenesis
GO:0030308	negative regulation of cell growth
GO:0035810	positive regulation of urine volume
GO:0035815	positive regulation of renal sodium excretion
GO:0042312	regulation of vasodilation
GO:0043114	regulation of vascular permeability
GO:0050880	regulation of blood vessel size

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0043234	protein complex

Orthologs

No orthologs found for this gene

Pathways

NETPATH

REACTOME

KEGG

INOH

PID NCI

Cross-References

SwissProt

P16860

TrEMBL

UniProt Splice Variant

Entrez Gene

4879

UniGene

RefSeq

NM_002521

HUGO

HGNC:7940

OMIM

600295

CCDS

CCDS140

HPRD

IMGT

EMBL

AB037521 AL021155 BC025785 CH471130 CR541976 CR542003 EU326309 M25296 M31776

GenPept

AAA35603 AAA36355 AAH25785 ACA05917 BAA90441 CAA15956 CAG46774 CAG46800 EAW71718

RNA Seq Atlas

4879