Homo sapiens Gene: NPPB
Summary
InnateDB Gene IDBG-89897.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NPPB
Gene Name natriuretic peptide B
Synonyms BNP;
Species Homo sapiens
Ensembl Gene ENSG00000120937
Encoded Proteins
natriuretic peptide B
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the natriuretic peptide family and encodes a secreted protein which functions as a cardiac hormone. The protein undergoes two cleavage events, one within the cell and a second after secretion into the blood. The protein's biological actions include natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and a key role in cardiovascular homeostasis. A high concentration of this protein in the bloodstream is indicative of heart failure. Mutations in this gene have been associated with postmenopausal osteoporosis. [provided by RefSeq, Jul 2008]
This gene is a member of the natriuretic peptide family and encodes a secreted protein which functions as a cardiac hormone. The protein undergoes two cleavage events, one within the cell and a second after secretion into the blood. The protein\'s biological actions include natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and a key role in cardiovascular homeostasis. A high concentration of this protein in the bloodstream is indicative of heart failure. Mutations in this gene have been associated with postmenopausal osteoporosis. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:11857464-11858931
Strand Reverse strand
Band p36.22
Transcripts
ENST00000376468 ENSP00000365651
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
Experimentally validated
Total 11 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005179 hormone activity
GO:0008613 diuretic hormone activity
Biological Process
GO:0006182 cGMP biosynthetic process
GO:0007166 cell surface receptor signaling pathway
GO:0007168 receptor guanylyl cyclase signaling pathway
GO:0007589 body fluid secretion
GO:0008217 regulation of blood pressure
GO:0016525 negative regulation of angiogenesis
GO:0030308 negative regulation of cell growth
GO:0035810 positive regulation of urine volume
GO:0035815 positive regulation of renal sodium excretion
GO:0042312 regulation of vasodilation
GO:0043114 regulation of vascular permeability
GO:0050880 regulation of blood vessel size
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0043234 protein complex
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
KEGG
INOH
PID BIOCARTA
Alk in cardiac myocytes [Biocarta view]
PID NCI
Cross-References
SwissProt P16860
TrEMBL
UniProt Splice Variant
Entrez Gene 4879
UniGene
RefSeq NM_002521
HUGO HGNC:7940
OMIM 600295
CCDS CCDS140
HPRD
IMGT
EMBL AB037521 AL021155 BC025785 CH471130 CR541976 CR542003 EU326309 M25296 M31776
GenPept AAA35603 AAA36355 AAH25785 ACA05917 BAA90441 CAA15956 CAG46774 CAG46800 EAW71718
RNA Seq Atlas 4879