InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NPPB

Summary

InnateDB Protein

IDBP-89899.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NPPB

Protein Name

natriuretic peptide B

Synonyms

BNP;

Species

Homo sapiens

Ensembl Protein

ENSP00000365651

InnateDB Gene

IDBG-89897 (NPPB)

Protein Structure

UniProt Annotation

Function

Cardiac hormone which may function as a paracrine antifibrotic factor in the heart. Also plays a key role in cardiovascular homeostasis through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3. {ECO:0000269PubMed:1672777}.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Brain and also in atria, but at much lower levels than ANP.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005179	hormone activity
GO:0008613	diuretic hormone activity

Biological Process

GO:0006182	cGMP biosynthetic process
GO:0007166	cell surface receptor signaling pathway
GO:0007168	receptor guanylyl cyclase signaling pathway
GO:0007589	body fluid secretion
GO:0008217	regulation of blood pressure
GO:0016525	negative regulation of angiogenesis
GO:0030308	negative regulation of cell growth
GO:0035810	positive regulation of urine volume
GO:0035815	positive regulation of renal sodium excretion
GO:0042312	regulation of vasodilation
GO:0043114	regulation of vascular permeability
GO:0050880	regulation of blood vessel size