|Homo sapiens Gene: MFN2|
|Last Modified||2014-10-13 [Report errors or provide feedback]|
|Gene Name||mitofusin 2|
|Synonyms||CMT2A; CMT2A2; CPRP1; HSG; MARF;|
|Useful resources||Stemformatics EHFPI ImmGen|
MFN2 deletion causes inability of the cell to undergo mitochondrial fusion, and therefore exhibit impaired induction of interferons and pro-inflammatory cytokines in response to viral infection - which results in increased viral replication.
|InnateDB Annotation from Orthologs|
[Mus musculus] Mfn2 deletion causes inability of the cell to undergo mitochondrial fusion, and therefore exhibit impaired induction of interferons and proinflammatory cytokines in response to viral infection - which results in increased viral replication.
[Mus musculus] Mitochondrial membrane potential is required for the association of Nlrp3 and Mfn2. Mfns2 is required for the activation of Nlrp3 inflammasomes.
This gene encodes a mitochondrial membrane protein that participates in mitochondrial fusion and contributes to the maintenance and operation of the mitochondrial network. This protein is involved in the regulation of vascular smooth muscle cell proliferation, and it may play a role in the pathophysiology of obesity. Mutations in this gene cause Charcot-Marie-Tooth disease type 2A2, and hereditary motor and sensory neuropathy VI, which are both disorders of the peripheral nervous system. Defects in this gene have also been associated with early-onset stroke. Two transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]
|Genomic Location||Chromosome 1:11980181-12013514|
|Number of Interactions||
This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Possible paralog/unusual divergence/ gene prediction error
Factors involved in megakaryocyte development and platelet production pathway
|UniProt Splice Variant|
|RefSeq||NM_001127660 XM_005263543 XM_005263548 NM_014874 XM_005263545 XM_005263547|
|EMBL||AF036536 AK289828 AL096840 AL137666 AY028429 BC017061 CH471130 D86987|
|GenPept||AAD02058 AAH17061 AAK18728 BAA34389 BAF82517 CAB70866 CAI19087 CAI19088 EAW71726|
|RNA Seq Atlas||9927|