InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: TNFRSF8

Summary

InnateDB Gene

IDBG-90058.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TNFRSF8

Gene Name

tumor necrosis factor receptor superfamily, member 8

Synonyms

CD30; D1S166E; Ki-1

Species

Homo sapiens

Ensembl Gene

ENSG00000120949

Encoded Proteins

IDBP-90060

tumor necrosis factor receptor superfamily, member 8

IDBP-369540

tumor necrosis factor receptor superfamily, member 8

IDBP-369546

tumor necrosis factor receptor superfamily, member 8

IDBP-482099

tumor necrosis factor receptor superfamily, member 8

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:12063377-12144207

Strand

Forward strand

Band

p36.22

Transcripts

ENST00000263932	ENSP00000263932
ENST00000417814	ENSP00000390650
ENST00000413146	ENSP00000398337
ENST00000514649	ENSP00000421938
ENST00000479933

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.

Experimentally validated
Total	20 [view]
Protein-Protein	20 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0005031	tumor necrosis factor-activated receptor activity
GO:0005515	protein binding

Biological Process

GO:0007165	signal transduction
GO:0008285	negative regulation of cell proliferation
GO:0033209	tumor necrosis factor-mediated signaling pathway
GO:0042535	positive regulation of tumor necrosis factor biosynthetic process
GO:0043065	positive regulation of apoptotic process
GO:0045556	positive regulation of TRAIL biosynthetic process
GO:0071260	cellular response to mechanical stimulus

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000028602

View Gene Order

ENSBTAG00000039937

Not yet available

Pathways

NETPATH

NetPath_9

TNFalpha pathway

REACTOME

KEGG

hsa04060

Cytokine-cytokine receptor interaction pathway

INOH

PID NCI

Cross-References

SwissProt

P28908

TrEMBL

UniProt Splice Variant

Entrez Gene

943

UniGene

Hs.1314

RefSeq

NM_001281430 NM_001243 XM_006711049

HUGO

HGNC:11923

OMIM

153243

CCDS

CCDS59989 CCDS144

HPRD

01074

IMGT

EMBL

AJ289159 AL357835 AY498860 BC063482 BC136400 D86042 M83554 S75768

GenPept

AAA51947 AAD14188 AAH63482 AAI36401 AAR32099 BAA12973 CAC16652

RNA Seq Atlas

943