InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TNFRSF8

Summary

InnateDB Protein

IDBP-369546.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TNFRSF8

Protein Name

tumor necrosis factor receptor superfamily, member 8

Synonyms

CD30; D1S166E; Ki-1;

Species

Homo sapiens

Ensembl Protein

ENSP00000398337

InnateDB Gene

IDBG-90058 (TNFRSF8)

Protein Structure

UniProt Annotation

Function

Receptor for TNFSF8/CD30L. May play a role in the regulation of cellular growth and transformation of activated lymphoblasts. Regulates gene expression through activation of NF- kappa-B.

Subcellular Localization

Isoform 1: Cell membrane; Single-pass type I membrane protein.Isoform 2: Cytoplasm.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.

Experimentally validated
Total	20 [view]
Protein-Protein	20 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0005031	tumor necrosis factor-activated receptor activity

Biological Process

GO:0007165	signal transduction
GO:0008285	negative regulation of cell proliferation
GO:0033209	tumor necrosis factor-mediated signaling pathway
GO:0042535	positive regulation of tumor necrosis factor biosynthetic process
GO:0043065	positive regulation of apoptotic process
GO:0045556	positive regulation of TRAIL biosynthetic process
GO:0071260	cellular response to mechanical stimulus