InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CD2AP

Summary

InnateDB Gene

IDBG-90083.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CD2AP

Gene Name

CD2-associated protein

Synonyms

CMS

Species

Homo sapiens

Ensembl Gene

ENSG00000198087

Encoded Proteins

IDBP-90087

CD2-associated protein

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a scaffolding molecule that regulates the actin cytoskeleton. The protein directly interacts with filamentous actin and a variety of cell membrane proteins through multiple actin binding sites, SH3 domains, and a proline-rich region containing binding sites for SH3 domains. The cytoplasmic protein localizes to membrane ruffles, lipid rafts, and the leading edges of cells. It is implicated in dynamic actin remodeling and membrane trafficking that occurs during receptor endocytosis and cytokinesis. Haploinsufficiency of this gene is implicated in susceptibility to glomerular disease. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:47477789-47627263

Strand

Forward strand

Band

p12.3

Transcripts

ENST00000359314	ENSP00000352264
ENST00000477159
ENST00000463175
ENST00000479857
ENST00000486693

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 96 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	96 [view]
Protein-Protein	93 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005200	structural constituent of cytoskeleton
GO:0005515	protein binding
GO:0017124	SH3 domain binding

Biological Process

GO:0006461	protein complex assembly
GO:0006930	substrate-dependent cell migration, cell extension
GO:0007067	mitotic nuclear division
GO:0007165	signal transduction
GO:0032911	negative regulation of transforming growth factor beta1 production
GO:1900182	positive regulation of protein localization to nucleus
GO:2000249	regulation of actin cytoskeleton reorganization

Cellular Component

GO:0001726	ruffle
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0015629	actin cytoskeleton
GO:0031941	filamentous actin
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000061665

View Gene Order

ENSBTAG00000000322

Not yet available

Pathways

NETPATH

NetPath_11

TCR pathway

REACTOME

REACT_23832

Nephrin interactions pathway

REACT_111155

Cell-Cell communication pathway

KEGG

hsa05100

Bacterial invasion of epithelial cells pathway

INOH

PID NCI

nephrin_neph1_pathway

Nephrin/Neph1 signaling in the kidney podocyte

vegfr1_pathway

VEGFR1 specific signals

Cross-References

SwissProt

Q9Y5K6

TrEMBL

UniProt Splice Variant

Entrez Gene

23607

UniGene

Hs.485518

RefSeq

NM_012120 XM_005248976 XM_005248977

HUGO

HGNC:14258

OMIM

604241

CCDS

CCDS34472

HPRD

IMGT

EMBL

AF146277 AF164377 AL050105 AL355353 AL358178 BC069444 CH471081

GenPept

AAD34595 AAF80495 AAH69444 CAB43274 CAH73238 CAI16839 EAX04319

RNA Seq Atlas

23607