InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CD2AP

Summary

InnateDB Protein

IDBP-90087.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CD2AP

Protein Name

CD2-associated protein

Synonyms

CMS;

Species

Homo sapiens

Ensembl Protein

ENSP00000352264

InnateDB Gene

IDBG-90083 (CD2AP)

Protein Structure

UniProt Annotation

Function

Seems to act as an adapter protein between membrane proteins and the actin cytoskeleton. In collaboration with CBLC, modulates the rate of RET turnover and may act as regulatory checkpoint that limits the potency of GDNF on neuronal survival. Controls CBLC function, converting it from an inhibitor to a promoter of RET degradation. May play a role in receptor clustering and cytoskeletal polarity in the junction between T- cell and antigen-presenting cell. May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glomerolus. Also required for cytokinesis. {ECO:0000269PubMed:15800069}.

Subcellular Localization

Cytoplasm, cytoskeleton {ECO:0000250}. Cell projection, ruffle {ECO:0000250}. Note=Colocalizes with F-actin and BCAR1/p130Cas in membrane ruffles. Located at podocyte slit diaphragm between podocyte foot processes (By similarity). During late anaphase and telophase, concentrates in the vicinity of the midzone microtubules and in the midbody in late telophase. {ECO:0000250, ECO:0000269PubMed:15800069}.

Disease Associations

Focal segmental glomerulosclerosis 3 (FSGS3) [MIM:607832]: A renal pathology defined by the presence of segmental sclerosis in glomeruli and resulting in proteinuria, reduced glomerular filtration rate and progressive decline in renal function. Renal insufficiency often progresses to end-stage renal disease, a highly morbid state requiring either dialysis therapy or kidney transplantation. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Tissue Specificity

Widely expressed in fetal and adult tissues.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 96 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	96 [view]
Protein-Protein	93 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005200	structural constituent of cytoskeleton
GO:0005515	protein binding
GO:0017124	SH3 domain binding

Biological Process

GO:0006461	protein complex assembly
GO:0006930	substrate-dependent cell migration, cell extension
GO:0007067	mitotic nuclear division
GO:0007165	signal transduction
GO:0032911	negative regulation of transforming growth factor beta1 production
GO:1900182	positive regulation of protein localization to nucleus
GO:2000249	regulation of actin cytoskeleton reorganization

Cellular Component

GO:0001726	ruffle
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0015629	actin cytoskeleton
GO:0031941	filamentous actin
GO:0070062	extracellular vesicular exosome