Homo sapiens Gene: DCLRE1A
Summary
InnateDB Gene IDBG-90190.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DCLRE1A
Gene Name DNA cross-link repair 1A
Synonyms PSO2; SNM1; SNM1A;
Species Homo sapiens
Ensembl Gene ENSG00000198924
Encoded Proteins
DNA cross-link repair 1A
DNA cross-link repair 1A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a conserved protein that is involved in the repair of DNA interstrand cross-links. DNA cross-links suppress transcription, replication, and DNA segregation. The encoded protein is a regulator of the mitotic cell cycle checkpoint. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:113834725-113854383
Strand Reverse strand
Band q25.3
Transcripts
ENST00000361384 ENSP00000355185
ENST00000369305 ENSP00000358311
ENST00000476112
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0016787 hydrolase activity
Biological Process
GO:0006289 nucleotide-excision repair
GO:0007067 mitotic nuclear division
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt Q6PJP8
TrEMBL
UniProt Splice Variant
Entrez Gene 9937
UniGene Hs.1560 Hs.703616 Hs.712962
RefSeq NM_001271816 NM_014881 XM_006718090
HUGO HGNC:17660
OMIM 609682
CCDS CCDS7584
HPRD 08519
IMGT
EMBL AL592546 AY607842 BC013124 BC062582 CH471066 D42045
GenPept AAH13124 AAH62582 AAT09762 BAA07646 CAI12637 EAW49489 EAW49490
RNA Seq Atlas 9937