Version 5.4
Homo sapiens Gene: DCLRE1A
Summary
InnateDB Gene IDBG-90190.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DCLRE1A
Gene Name DNA cross-link repair 1A
Synonyms PSO2; SNM1; SNM1A
Species Homo sapiens
Ensembl Gene ENSG00000198924
Encoded Proteins
IDBP-90192
DNA cross-link repair 1A
IDBP-90194
DNA cross-link repair 1A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a conserved protein that is involved in the repair of DNA interstrand cross-links. DNA cross-links suppress transcription, replication, and DNA segregation. The encoded protein is a regulator of the mitotic cell cycle checkpoint. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:113834725-113854383
Strand Reverse strand
Band q25.3
Transcripts
ENST00000361384 ENSP00000355185
ENST00000369305 ENSP00000358311
ENST00000476112
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0016787 hydrolase activity
Biological Process
GO:0006289 nucleotide-excision repair
GO:0007067 mitotic nuclear division
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000025077
View Gene Order
ENSBTAG00000020193
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.1560 Hs.703616 Hs.712962
RefSeq NM_001271816 NM_014881 XM_006718090
HUGO
OMIM
CCDS CCDS7584
HPRD 08519
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca