InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: TTF1

Summary

InnateDB Gene

IDBG-90279.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TTF1

Gene Name

transcription termination factor, RNA polymerase I

Synonyms

TTF-1; TTF-I

Species

Homo sapiens

Ensembl Gene

ENSG00000125482

Encoded Proteins

IDBP-90281

transcription termination factor, RNA polymerase I

IDBP-809101

transcription termination factor, RNA polymerase I

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a transcription termination factor that is localized to the nucleolus and plays a critical role in ribosomal gene transcription. The encoded protein mediates the termination of RNA polymerase I transcription by binding to Sal box terminator elements downstream of pre-rRNA coding regions. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. This gene shares the symbol/alias 'TFF1' with another gene, NK2 homeobox 1, also known as thyroid transcription factor 1, which plays a role in the regulation of thyroid-specific gene expression. [provided by RefSeq, Apr 2011]
This gene encodes a transcription termination factor that is localized to the nucleolus and plays a critical role in ribosomal gene transcription. The encoded protein mediates the termination of RNA polymerase I transcription by binding to Sal box terminator elements downstream of pre-rRNA coding regions. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. This gene shares the symbol/alias \'TFF1\' with another gene, NK2 homeobox 1, also known as thyroid transcription factor 1, which plays a role in the regulation of thyroid-specific gene expression. [provided by RefSeq, Apr 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:132375548-132406851

Strand

Reverse strand

Band

q34.13

Transcripts

ENST00000334270	ENSP00000333920
ENST00000461970
ENST00000612514	ENSP00000481441

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	15 [view]
Protein-Protein	12 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0005515	protein binding

Biological Process

GO:0006338	chromatin remodeling
GO:0006353	DNA-dependent transcription, termination
GO:0006355	regulation of transcription, DNA-templated
GO:0006360	transcription from RNA polymerase I promoter
GO:0006361	transcription initiation from RNA polymerase I promoter
GO:0006363	termination of RNA polymerase I transcription
GO:0008156	negative regulation of DNA replication
GO:0010467	gene expression