InnateDB Protein
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IDBP-90281.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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TTF1
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Protein Name
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transcription termination factor, RNA polymerase I
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Synonyms
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TTF-1; TTF-I;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000333920
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InnateDB Gene
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IDBG-90279 (TTF1)
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Protein Structure
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Function |
Multifunctional nucleolar protein that terminates ribosomal gene transcription, mediates replication fork arrest and regulates RNA polymerase I transcription on chromatin. Plays a dual role in rDNA regulation, being involved in both activation and silencing of rDNA transcription. Interaction with BAZ2A/TIP5 recovers DNA-binding activity. {ECO:0000269PubMed:7597036}.
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Subcellular Localization |
Nucleus. Nucleus, nucleolus {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated |
Total |
15
[view]
|
Protein-Protein |
12
[view]
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Protein-DNA |
3
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
3 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001005
SANT/Myb domain
IPR009057
Homeodomain-like
IPR017877
Myb-like domain
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PFAM |
PF00249
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PRINTS |
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PIRSF |
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SMART |
SM00717
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TIGRFAMs |
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Modification |
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SwissProt |
Q15361
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PhosphoSite |
PhosphoSite-Q15361
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TrEMBL |
A0A024R8C1
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UniProt Splice Variant |
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Entrez Gene |
7270
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UniGene |
Hs.54780
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RefSeq |
NP_031370
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HUGO |
HGNC:12397
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OMIM |
600777
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CCDS |
CCDS6948
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HPRD |
02866
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IMGT |
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EMBL |
AL353701
BC050734
BC062692
BC104639
BC127669
BC127670
BC143048
BC143049
CH471090
X83973
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GenPept |
AAH50734
AAH62692
AAI04640
AAI27670
AAI27671
AAI43049
AAI43050
CAA58807
CAI94997
EAW88001
EAW88002
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