InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TTF1

Summary

InnateDB Protein

IDBP-90281.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TTF1

Protein Name

transcription termination factor, RNA polymerase I

Synonyms

TTF-1; TTF-I;

Species

Homo sapiens

Ensembl Protein

ENSP00000333920

InnateDB Gene

IDBG-90279 (TTF1)

Protein Structure

UniProt Annotation

Function

Multifunctional nucleolar protein that terminates ribosomal gene transcription, mediates replication fork arrest and regulates RNA polymerase I transcription on chromatin. Plays a dual role in rDNA regulation, being involved in both activation and silencing of rDNA transcription. Interaction with BAZ2A/TIP5 recovers DNA-binding activity. {ECO:0000269PubMed:7597036}.

Subcellular Localization

Nucleus. Nucleus, nucleolus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	15 [view]
Protein-Protein	12 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0005515	protein binding

Biological Process

GO:0006338	chromatin remodeling
GO:0006353	DNA-dependent transcription, termination
GO:0006355	regulation of transcription, DNA-templated
GO:0006360	transcription from RNA polymerase I promoter
GO:0006361	transcription initiation from RNA polymerase I promoter
GO:0006363	termination of RNA polymerase I transcription
GO:0008156	negative regulation of DNA replication
GO:0010467	gene expression