Version 5.4
Homo sapiens Gene: FBXO9
Summary
InnateDB Gene IDBG-90954.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FBXO9
Gene Name F-box protein 9
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000112146
Encoded Proteins
IDBP-90956
F-box protein 9
IDBP-90958
F-box protein 9
IDBP-90960
F-box protein 9
IDBP-480770
F-box protein 9
IDBP-480241
F-box protein 9
IDBP-482730
F-box protein 9
IDBP-809617
F-box protein 9
IDBP-473603
F-box protein 9
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternative splicing of this gene generates at least 3 transcript variants diverging at the 5' terminus. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:53051991-53100873
Strand Forward strand
Band p12.1
Transcripts
ENST00000323557 ENSP00000326968
ENST00000244426 ENSP00000244426
ENST00000370939 ENSP00000359977
ENST00000459845 ENSP00000417154
ENST00000498744 ENSP00000418858
ENST00000461222
ENST00000473337 ENSP00000420536
ENST00000468481
ENST00000480463
ENST00000484812
ENST00000474457
ENST00000484436 ENSP00000477487
ENST00000473318 ENSP00000417349
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
Experimentally validated
Total 15 [view]
Protein-Protein 15 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
Biological Process
GO:0016567 protein ubiquitination
GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0032006 regulation of TOR signaling
GO:0045087 innate immune response
GO:0045444 fat cell differentiation
Cellular Component
GO:0000151 ubiquitin ligase complex
GO:0005737 cytoplasm
GO:0019005 SCF ubiquitin ligase complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000001366
View Gene Order
ENSBTAG00000015083
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.216653 Hs.597310 Hs.618690 Hs.649202
RefSeq NM_012347 NM_033480 NM_033481 XM_005248995 XM_005248996
HUGO
OMIM
CCDS CCDS55022 CCDS55023 CCDS55024
HPRD 16434
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca