InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: RPL7A

Summary

InnateDB Gene

IDBG-91022.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RPL7A

Gene Name

ribosomal protein L7a

Synonyms

L7A; SURF3; TRUP

Species

Homo sapiens

Ensembl Gene

ENSG00000148303

Encoded Proteins

IDBP-91026

ribosomal protein L7a

IDBP-91030

ribosomal protein L7a

IDBP-383322

ribosomal protein L7a

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Cytoplasmic ribosomes, organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L7AE family of ribosomal proteins. It can interact with a subclass of nuclear hormone receptors, including thyroid hormone receptor, and inhibit their ability to transactivate by preventing their binding to their DNA response elements. This gene is included in the surfeit gene cluster, a group of very tightly linked genes that do not share sequence similarity. It is co-transcribed with the U24, U36a, U36b, and U36c small nucleolar RNA genes, which are located in its second, fifth, fourth, and sixth introns, respectively. This gene rearranges with the trk proto-oncogene to form the chimeric oncogene trk-2h, which encodes an oncoprotein consisting of the N terminus of ribosomal protein L7a fused to the receptor tyrosine kinase domain of trk. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:133348214-133351426

Strand

Forward strand

Band

q34.2

Transcripts

ENST00000323345	ENSP00000361076
ENST00000315731	ENSP00000361071
ENST00000426651	ENSP00000416638
ENST00000463740
ENST00000496554
ENST00000468019
ENST00000485706
ENST00000489392
ENST00000492798

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 135 experimentally validated interaction(s) in this database.

Experimentally validated
Total	135 [view]
Protein-Protein	135 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0006412	translation
GO:0006413	translational initiation
GO:0006414	translational elongation
GO:0006415	translational termination
GO:0006614	SRP-dependent cotranslational protein targeting to membrane
GO:0010467	gene expression
GO:0016032	viral process
GO:0016070	RNA metabolic process
GO:0016071	mRNA metabolic process
GO:0019058	viral life cycle
GO:0019083	viral transcription
GO:0042254	ribosome biogenesis
GO:0044267	cellular protein metabolic process

Cellular Component

GO:0005634	nucleus
GO:0005829	cytosol
GO:0005840	ribosome
GO:0016020	membrane
GO:0022625	cytosolic large ribosomal subunit
GO:0042788	polysomal ribosome
GO:0070062	extracellular vesicular exosome