InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: GRK5

Summary

InnateDB Gene

IDBG-91131.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GRK5

Gene Name

G protein-coupled receptor kinase 5

Synonyms

GPRK5

Species

Homo sapiens

Ensembl Gene

ENSG00000198873

Encoded Proteins

IDBP-244779

G protein-coupled receptor kinase 5

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 20945396

GRK5 is a serine/threonine kinase has a role in the regulation of G-protein coupled receptor (GPCR) signalling and is also an important regulator of signalling pathways stimulated by non-GPCRs. GRK5 also is a positive regulator of TLR4-induced I-kappa-B-alpha-NFkappaB pathway as well as a key modulator of lipopolysaccharide-induced inflammatory response.

Entrez Gene

Summary

This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. It has also been shown to play a role in regulating the motility of polymorphonuclear leukocytes (PMNs). [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:119207589-119459742

Strand

Forward strand

Band

q26.11

Transcripts

ENST00000369108
ENST00000392870	ENSP00000376609

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 193 experimentally validated interaction(s) in this database.

Experimentally validated
Total	193 [view]
Protein-Protein	193 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004703	G-protein coupled receptor kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005080	protein kinase C binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0005543	phospholipid binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468	protein phosphorylation
GO:0006915	apoptotic process
GO:0007165	signal transduction
GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0007217	tachykinin receptor signaling pathway
GO:0008277	regulation of G-protein coupled receptor protein signaling pathway
GO:0016055	Wnt signaling pathway
GO:0038032	termination of G-protein coupled receptor signaling pathway
GO:0043066	negative regulation of apoptotic process
GO:0045087	innate immune response (InnateDB)
GO:0046777	protein autophosphorylation