InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: GRK5

Summary

InnateDB Gene

IDBG-91131.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GRK5

Gene Name

G protein-coupled receptor kinase 5

Synonyms

GPRK5;

Species

Homo sapiens

Ensembl Gene

ENSG00000198873

Encoded Proteins

IDBP-244779

G protein-coupled receptor kinase 5

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 20945396

GRK5 is a serine/threonine kinase has a role in the regulation of G-protein coupled receptor (GPCR) signalling and is also an important regulator of signalling pathways stimulated by non-GPCRs. GRK5 also is a positive regulator of TLR4-induced I-kappa-B-alpha-NFkappaB pathway as well as a key modulator of lipopolysaccharide-induced inflammatory response.

Entrez Gene

Summary

This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. It has also been shown to play a role in regulating the motility of polymorphonuclear leukocytes (PMNs). [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:119207589-119459742

Strand

Forward strand

Band

q26.11

Transcripts

ENST00000369108
ENST00000392870	ENSP00000376609

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 193 experimentally validated interaction(s) in this database.

Experimentally validated
Total	193 [view]
Protein-Protein	193 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004703	G-protein coupled receptor kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005080	protein kinase C binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0005543	phospholipid binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468	protein phosphorylation
GO:0006915	apoptotic process
GO:0007165	signal transduction
GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0007217	tachykinin receptor signaling pathway
GO:0008277	regulation of G-protein coupled receptor protein signaling pathway
GO:0016055	Wnt signaling pathway
GO:0038032	termination of G-protein coupled receptor signaling pathway
GO:0043066	negative regulation of apoptotic process
GO:0045087	innate immune response (InnateDB)
GO:0046777	protein autophosphorylation

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005886	plasma membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

Method

Confidence

Comments

ENSMUSG00000003228

View Gene Order

Ortholuge

SSD Ortholog

Ortholog supports species divergence

ENSBTAG00000007981

Not yet available

Ortholuge

SSD Ortholog

Ortholog supports species divergence

Pathways

NETPATH

REACTOME

REACT_120966

Gastrin-CREB signalling pathway via PKC and MAPK pathway

REACT_18283

G alpha (q) signalling events pathway

REACT_14797

Signaling by GPCR pathway

REACT_111102

Signal Transduction pathway

REACT_19184

GPCR downstream signaling pathway

KEGG

hsa04062

Chemokine signaling pathway pathway

hsa04144

Endocytosis pathway

INOH

INOH website

IL-7 signaling pathway

INOH website

JAK STAT pathway and regulation pathway

INOH website

EPO signaling pathway pathway

INOH website

VEGF signaling pathway pathway

PID BIOCARTA

PID NCI

alphasynuclein_pathway

Alpha-synuclein signaling

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.524625

RefSeq

NM_005308

HUGO

OMIM

CCDS

CCDS7612

HPRD

02926

IMGT

EMBL

GenPept

RNA Seq Atlas