Version 5.4
| Homo sapiens Gene: SURF4 | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-91141.6 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | SURF4 | ||||||||||||||||||
| Gene Name | surfeit 4 | ||||||||||||||||||
| Synonyms | ERV29 | ||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||
| Ensembl Gene | ENSG00000148248 | ||||||||||||||||||
| Encoded Proteins |
surfeit 4
surfeit 4
surfeit 4
surfeit 4
surfeit 4
surfeit 4
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| Protein Structure | |||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| Summary |
This gene is located in the surfeit gene cluster, which is comprised of very tightly linked housekeeping genes that do not share sequence similarity. The encoded protein is a conserved integral membrane protein containing multiple putative transmembrane regions. In eukaryotic cells, protein transport between the endoplasmic reticulum and Golgi compartments is mediated in part by non-clathrin-coated vesicular coat proteins (COPs). The specific function of this protein has not been determined but its yeast homolog is directly required for packaging glycosylated pro-alpha-factor into COPII vesicles. This gene uses multiple polyadenylation sites, resulting in transcript length variation. The existence of alternatively spliced transcript variants has been suggested, but their validity has not been determined. [provided by RefSeq, Jul 2008] This gene is located in the surfeit gene cluster, which is comprised of very tightly linked housekeeping genes that do not share sequence similarity. The encoded protein is a conserved integral membrane protein that interacts with endoplasmic reticulum-Golgi intermediate compartment proteins. Disruption of this gene results in reduced numbers of endoplasmic reticulum-Golgi intermediate compartment clusters and redistribution of coat protein I to the cytosol. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013] |
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| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 9:133361449-133376166 | ||||||||||||||||||
| Strand | Reverse strand | ||||||||||||||||||
| Band | q34.2 | ||||||||||||||||||
| Transcripts | |||||||||||||||||||
| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 36 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||
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Species
Mus musculus
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Gene ID
Gene Order
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| Cross-References | |||||||||||||||||||
| SwissProt | |||||||||||||||||||
| TrEMBL | B7Z1G8 | ||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | 6836 | ||||||||||||||||||
| UniGene | |||||||||||||||||||
| RefSeq | NM_001280790 NM_001280788 NM_001280789 NM_001280791 NM_001280792 NM_033161 XM_006717257 | ||||||||||||||||||
| HUGO | HGNC:11476 | ||||||||||||||||||
| OMIM | 185660 | ||||||||||||||||||
| CCDS | CCDS75929 CCDS65177 CCDS65178 CCDS6968 | ||||||||||||||||||
| HPRD | |||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | AK293434 AK295435 AK316480 CH471090 | ||||||||||||||||||
| GenPept | BAH11504 BAH12067 BAH14851 EAW88072 EAW88073 | ||||||||||||||||||
| RNA Seq Atlas | 6836 | ||||||||||||||||||