Version 5.4
Homo sapiens Gene: ZBTB17
Summary
InnateDB Gene IDBG-91200.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ZBTB17
Gene Name zinc finger and BTB domain containing 17
Synonyms MIZ-1; pHZ-67; ZNF151; ZNF60
Species Homo sapiens
Ensembl Gene ENSG00000116809
Encoded Proteins
IDBP-91202
zinc finger and BTB domain containing 17
IDBP-91204
zinc finger and BTB domain containing 17
IDBP-371311
zinc finger and BTB domain containing 17
IDBP-371367
zinc finger and BTB domain containing 17
IDBP-603870
zinc finger and BTB domain containing 17
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a zinc finger protein involved in the regulation of c-myc. The symbol MIZ1 has also been associated with PIAS2 which is a different gene located on chromosome 18. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:15941869-15976132
Strand Reverse strand
Band p36.13
Transcripts
ENST00000375743 ENSP00000364895
ENST00000375733 ENSP00000364885
ENST00000440560 ENSP00000400827
ENST00000444358 ENSP00000408483
ENST00000462525
ENST00000488008
ENST00000471805
ENST00000472658
ENST00000474511
ENST00000487785
ENST00000492834
ENST00000490899
ENST00000464719
ENST00000479282
ENST00000494020
ENST00000537142 ENSP00000438529
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 38 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 38 [view]
Protein-Protein 33 [view]
Protein-DNA 5 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0001702 gastrulation with mouth forming second
GO:0006351 transcription, DNA-templated
GO:0006987 activation of signaling protein activity involved in unfolded protein response
GO:0007398 ectoderm development
GO:0030968 endoplasmic reticulum unfolded protein response
GO:0044267 cellular protein metabolic process
GO:0045786 negative regulation of cell cycle
GO:0045893 positive regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000006215
View Gene Order
ENSBTAG00000018730
Not yet available
Pathways
NETPATH
NetPath_9
TNFalpha pathway
REACTOME
REACT_18273
XBP1(S) activates chaperone genes pathway
REACT_18368
IRE1alpha activates chaperones pathway
REACT_18356
Unfolded Protein Response (UPR) pathway
REACT_17015
Metabolism of proteins pathway
KEGG
hsa04110
Cell cycle pathway
INOH
PID NCI
myc_represspathway
Validated targets of C-MYC transcriptional repression
myc_pathway
C-MYC pathway
smad2_3nuclearpathway
Regulation of nuclear SMAD2/3 signaling
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.433764
RefSeq NM_001242884 NM_001287603 NM_001287604 NM_003443 XM_005245987
HUGO
OMIM
CCDS CCDS165 CCDS55576 CCDS72712
HPRD 04968
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca