Homo sapiens Gene: ZBTB17
Summary
InnateDB Gene IDBG-91200.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ZBTB17
Gene Name zinc finger and BTB domain containing 17
Synonyms MIZ-1; pHZ-67; ZNF151; ZNF60;
Species Homo sapiens
Ensembl Gene ENSG00000116809
Encoded Proteins
zinc finger and BTB domain containing 17
zinc finger and BTB domain containing 17
zinc finger and BTB domain containing 17
zinc finger and BTB domain containing 17
zinc finger and BTB domain containing 17
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a zinc finger protein involved in the regulation of c-myc. The symbol MIZ1 has also been associated with PIAS2 which is a different gene located on chromosome 18. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:15941869-15976132
Strand Reverse strand
Band p36.13
Transcripts
ENST00000375743 ENSP00000364895
ENST00000375733 ENSP00000364885
ENST00000440560 ENSP00000400827
ENST00000444358 ENSP00000408483
ENST00000462525
ENST00000488008
ENST00000471805
ENST00000472658
ENST00000474511
ENST00000487785
ENST00000492834
ENST00000490899
ENST00000464719
ENST00000479282
ENST00000494020
ENST00000537142 ENSP00000438529
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 38 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 38 [view]
Protein-Protein 33 [view]
Protein-DNA 5 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0001702 gastrulation with mouth forming second
GO:0006351 transcription, DNA-templated
GO:0006987 activation of signaling protein activity involved in unfolded protein response
GO:0007398 ectoderm development
GO:0030968 endoplasmic reticulum unfolded protein response
GO:0044267 cellular protein metabolic process
GO:0045786 negative regulation of cell cycle
GO:0045893 positive regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
TNFalpha pathway
REACTOME
IRE1alpha activates chaperones pathway
Unfolded Protein Response (UPR) pathway
XBP1(S) activates chaperone genes pathway
Metabolism of proteins pathway
KEGG
Cell cycle pathway
INOH
PID BIOCARTA
PID NCI
Validated targets of C-MYC transcriptional repression
C-MYC pathway
Regulation of nuclear SMAD2/3 signaling
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 7709
UniGene Hs.433764
RefSeq NM_001242884 NM_001287603 NM_001287604 NM_003443 XM_005245987
HUGO HGNC:12936
OMIM 604084
CCDS CCDS165 CCDS55576 CCDS72712
HPRD 04968
IMGT
EMBL
GenPept
RNA Seq Atlas 7709