InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ZBTB17

Summary

InnateDB Protein

IDBP-91204.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ZBTB17

Protein Name

zinc finger and BTB domain containing 17

Synonyms

MIZ-1; pHZ-67; ZNF151; ZNF60;

Species

Homo sapiens

Ensembl Protein

ENSP00000364885

InnateDB Gene

IDBG-91200 (ZBTB17)

Protein Structure

UniProt Annotation

Function

Transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. Plays a critical role in early lymphocyte development, where it is essential to prevent apoptosis in lymphoid precursors, allowing them to survive in response to IL7 and undergo proper lineage commitment. Has been shown to bind to the promoters of adenovirus major late protein and cyclin D1 and activate transcription. Required for early embryonic development during gastrulation. {ECO:0000269PubMed:16142238, ECO:0000269PubMed:19164764, ECO:0000269PubMed:9308237, ECO:0000269PubMed:9312026}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:14739298, ECO:0000269PubMed:9312026}.

Disease Associations

Tissue Specificity

Expressed in germinal center B-cells. {ECO:0000269PubMed:16142238}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 38 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	38 [view]
Protein-Protein	33 [view]
Protein-DNA	5 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0046872	metal ion binding

Biological Process

GO:0001702	gastrulation with mouth forming second
GO:0006351	transcription, DNA-templated
GO:0006987	activation of signaling protein activity involved in unfolded protein response
GO:0007398	ectoderm development
GO:0030968	endoplasmic reticulum unfolded protein response
GO:0044267	cellular protein metabolic process
GO:0045786	negative regulation of cell cycle
GO:0045893	positive regulation of transcription, DNA-templated