InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: GDI1

Summary

InnateDB Gene

IDBG-91478.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GDI1

Gene Name

GDP dissociation inhibitor 1

Synonyms

1A; GDIL; MRX41; MRX48; OPHN2; RABGD1A; RABGDIA; XAP-4

Species

Homo sapiens

Ensembl Gene

ENSG00000203879

Encoded Proteins

IDBP-383680

GDP dissociation inhibitor 1

IDBP-383681

GDP dissociation inhibitor 1

IDBP-383682

GDP dissociation inhibitor 1

IDBP-383683

GDP dissociation inhibitor 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

GDP dissociation inhibitors are proteins that regulate the GDP-GTP exchange reaction of members of the rab family, small GTP-binding proteins of the ras superfamily, that are involved in vesicular trafficking of molecules between cellular organelles. GDIs slow the rate of dissociation of GDP from rab proteins and release GDP from membrane-bound rabs. GDI1 is expressed primarily in neural and sensory tissues. Mutations in GDI1 have been linked to X-linked nonspecific mental retardation. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:154436920-154443467

Strand

Forward strand

Band

q28

Transcripts

ENST00000447750	ENSP00000394071
ENST00000445564	ENSP00000394752
ENST00000434049	ENSP00000416195
ENST00000415109	ENSP00000396215
ENST00000475976
ENST00000481304
ENST00000485143
ENST00000491154
ENST00000489589
ENST00000471972
ENST00000468483
ENST00000476540
ENST00000465640
ENST00000460984

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 38 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	38 [view]
Protein-Protein	37 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005092	GDP-dissociation inhibitor activity
GO:0005093	Rab GDP-dissociation inhibitor activity
GO:0005096	GTPase activator activity
GO:0005515	protein binding
GO:0017137	Rab GTPase binding

Biological Process

GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0015031	protein transport
GO:0032482	Rab protein signal transduction
GO:0043547	positive regulation of GTPase activity
GO:0050771	negative regulation of axonogenesis
GO:0050790	regulation of catalytic activity
GO:0051056	regulation of small GTPase mediated signal transduction
GO:0051592	response to calcium ion
GO:0090315	negative regulation of protein targeting to membrane

Cellular Component

GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0005829	cytosol
GO:0030496	midbody
GO:0043005	neuron projection
GO:0043234	protein complex

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000015291

View Gene Order

ENSBTAG00000012125

Not yet available

Pathways

NETPATH

REACTOME

REACT_11051

Rho GTPase cycle pathway

REACT_11044

Signaling by Rho GTPases pathway

REACT_111102

Signal Transduction pathway

KEGG

INOH

PID NCI

p38alphabetadownstreampathway

Signaling mediated by p38-alpha and p38-beta

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.74576

RefSeq

NM_001493

HUGO

OMIM

CCDS

CCDS35452

HPRD

02114

IMGT

EMBL

GenPept

RNA Seq Atlas