Mus musculus Gene: Gdi1
Summary
InnateDB Gene IDBG-155873.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Gdi1
Gene Name guanosine diphosphate (GDP) dissociation inhibitor 1
Synonyms GDIA; GDIalpha;
Species Mus musculus
Ensembl Gene ENSMUSG00000015291
Encoded Proteins
guanosine diphosphate (GDP) dissociation inhibitor 1
guanosine diphosphate (GDP) dissociation inhibitor 1
guanosine diphosphate (GDP) dissociation inhibitor 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000203879:
GDP dissociation inhibitors are proteins that regulate the GDP-GTP exchange reaction of members of the rab family, small GTP-binding proteins of the ras superfamily, that are involved in vesicular trafficking of molecules between cellular organelles. GDIs slow the rate of dissociation of GDP from rab proteins and release GDP from membrane-bound rabs. GDI1 is expressed primarily in neural and sensory tissues. Mutations in GDI1 have been linked to X-linked nonspecific mental retardation. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome X:74304998-74311862
Strand Forward strand
Band A7.3
Transcripts
ENSMUST00000015435 ENSMUSP00000015435
ENSMUST00000146013
ENSMUST00000145580
ENSMUST00000149391
ENSMUST00000153141 ENSMUSP00000119805
ENSMUST00000128915
ENSMUST00000144317
ENSMUST00000130581 ENSMUSP00000122146
ENSMUST00000137447
ENSMUST00000135041
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 23 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005093 Rab GDP-dissociation inhibitor activity
GO:0005096 GTPase activator activity
GO:0005515 protein binding
GO:0017137 Rab GTPase binding
Biological Process
GO:0015031 protein transport
GO:0032482 Rab protein signal transduction
GO:0043547 positive regulation of GTPase activity
GO:0050771 negative regulation of axonogenesis
GO:0050790 regulation of catalytic activity
GO:0051592 response to calcium ion
GO:0090315 negative regulation of protein targeting to membrane
Cellular Component
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0030496 midbody
GO:0043005 neuron projection
GO:0043234 protein complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Signaling by Rho GTPases pathway
Rho GTPase cycle pathway
Signal Transduction pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Signaling by Rho GTPases pathway
Signal Transduction pathway
Rho GTPase cycle pathway
Rho GTPase cycle pathway
Signal Transduction pathway
Signaling by Rho GTPases pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Signaling mediated by p38-alpha and p38-beta
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.205830 Mm.392083
RefSeq NM_010273
OMIM
CCDS CCDS30227
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas