Homo sapiens Gene: SDHB
Summary
InnateDB Gene IDBG-91733.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SDHB
Gene Name succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
Synonyms CWS2; IP; PGL4; SDH; SDH1; SDH2; SDHIP;
Species Homo sapiens
Ensembl Gene ENSG00000117118
Encoded Proteins
succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:17018722-17054170
Strand Reverse strand
Band p36.13
Transcripts
ENST00000375499 ENSP00000364649
ENST00000475049
ENST00000485092
ENST00000485515
ENST00000491274 ENSP00000480482
ENST00000475506
ENST00000463045 ENSP00000481376
ENST00000466613
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 47 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 47 [view]
Protein-Protein 47 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008177 succinate dehydrogenase (ubiquinone) activity
GO:0009055 electron carrier activity
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding
GO:0048039 ubiquinone binding
GO:0051536 iron-sulfur cluster binding
GO:0051537 2 iron, 2 sulfur cluster binding
GO:0051538 3 iron, 4 sulfur cluster binding
GO:0051539 4 iron, 4 sulfur cluster binding
Biological Process
GO:0006099 tricarboxylic acid cycle
GO:0006105 succinate metabolic process
GO:0009060 aerobic respiration
GO:0022904 respiratory electron transport chain
GO:0044237 cellular metabolic process
GO:0044281 small molecule metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005749 mitochondrial respiratory chain complex II
GO:0045273 respiratory chain complex II
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Pyruvate metabolism and Citric Acid (TCA) cycle pathway
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. pathway
Citric acid cycle (TCA cycle) pathway
The citric acid (TCA) cycle and respiratory electron transport pathway
Metabolism pathway
Respiratory electron transport pathway
KEGG
Citrate cycle (TCA cycle) pathway
Oxidative phosphorylation pathway
Alzheimer's disease pathway
Parkinson's disease pathway
Huntington's disease pathway
INOH
Arginine Proline metabolism pathway
Citrate cycle pathway
Tyrosine metabolism pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_003000
HUGO
OMIM
CCDS CCDS176
HPRD 01707
IMGT
EMBL
GenPept
RNA Seq Atlas