Homo sapiens Gene: MACC1
Summary
InnateDB Gene IDBG-9175.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MACC1
Gene Name metastasis associated in colon cancer 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000183742
Encoded Proteins
metastasis associated in colon cancer 1
metastasis associated in colon cancer 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary MACC1 is a key regulator of the hepatocyte growth factor (HGF; MIM 142409)-HGF receptor (HGFR, or MET; MIM 164860) pathway, which is involved in cellular growth, epithelial-mesenchymal transition, angiogenesis, cell motility, invasiveness, and metastasis. Expression of MACC1 in colon cancer (MIM 114500) specimens is an independent prognostic indicator for metastasis formation and metastasis-free survival (Stein et al., 2009 [PubMed 19098908]).[supplied by OMIM, Mar 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:20134655-20217404
Strand Reverse strand
Band p21.1
Transcripts
ENST00000332878 ENSP00000328410
ENST00000400331 ENSP00000383185
ENST00000471019
ENST00000483317
ENST00000589011 ENSP00000466864
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008083 growth factor activity
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0051781 positive regulation of cell division
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.598388
RefSeq NM_182762
HUGO
OMIM
CCDS CCDS5369
HPRD 12381
IMGT
EMBL
GenPept
RNA Seq Atlas