Version 5.4
Homo sapiens Gene: CLIC2
Summary
InnateDB Gene IDBG-92452.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CLIC2
Gene Name chloride intracellular channel 2
Synonyms CLIC2b; MRXS32; XAP121
Species Homo sapiens
Ensembl Gene ENSG00000155962
Encoded Proteins
IDBP-89809
chloride intracellular channel 2
IDBP-92454
chloride intracellular channel 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 2 is a member of the p64 family; the protein is detected in fetal liver and adult skeletal muscle tissue. This gene maps to the candidate region on chromosome X for incontinentia pigmenti. [provided by RefSeq, Jul 2008]
This gene encodes a chloride intracellular channel protein. Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. This protein may play a role in inhibiting the function of ryanodine receptor 2. A mutation in this gene is the cause of X-linked mental retardation-32. [provided by RefSeq, Aug 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome X:155276211-155334657
Strand Reverse strand
Band q28
Transcripts
ENST00000321926 ENSP00000318558
ENST00000369449 ENSP00000358460
ENST00000465553
ENST00000491205
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004602 glutathione peroxidase activity
GO:0005247 voltage-gated chloride channel activity
GO:0005254 chloride channel activity
GO:0005515 protein binding
Biological Process
GO:0006810 transport
GO:0006821 chloride transport
GO:0007165 signal transduction
GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
GO:0044070 regulation of anion transport
GO:0051099 positive regulation of binding
GO:0055114 oxidation-reduction process
GO:0060315 negative regulation of ryanodine-sensitive calcium-release channel activity
GO:1902476 chloride transmembrane transport
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0034707 chloride channel complex
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_160189
Stimuli-sensing channels pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_25300
Ion channel transport pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL A6PVS0
UniProt Splice Variant
Entrez Gene 1193
UniGene Hs.610573 Hs.655445
RefSeq NM_001289
HUGO HGNC:2063
OMIM 300138
CCDS CCDS14767
HPRD 02139
IMGT
EMBL AL356738
GenPept CAO77905
RNA Seq Atlas 1193

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca