Homo sapiens Gene: AGPAT2
Summary
InnateDB Gene IDBG-92546.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AGPAT2
Gene Name 1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta)
Synonyms 1-AGPAT2; BSCL; BSCL1; LPAAB; LPAAT-beta;
Species Homo sapiens
Ensembl Gene ENSG00000169692
Encoded Proteins
1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta)
1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta)
1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the 1-acylglycerol-3-phosphate O-acyltransferase family. The protein is located within the endoplasmic reticulum membrane and converts lysophosphatidic acid to phosphatidic acid, the second step in de novo phospholipid biosynthesis. Mutations in this gene have been associated with congenital generalized lipodystrophy (CGL), or Berardinelli-Seip syndrome, a disease characterized by a near absence of adipose tissue and severe insulin resistance. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:136673143-136687423
Strand Reverse strand
Band q34.3
Transcripts
ENST00000371696 ENSP00000360761
ENST00000371694 ENSP00000360759
ENST00000472820
ENST00000470861
ENST00000538402 ENSP00000438919
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity
GO:0016746 transferase activity, transferring acyl groups
Biological Process
GO:0001819 positive regulation of cytokine production
GO:0001961 positive regulation of cytokine-mediated signaling pathway
GO:0006644 phospholipid metabolic process
GO:0006654 phosphatidic acid biosynthetic process
GO:0008152 metabolic process
GO:0008544 epidermis development
GO:0008654 phospholipid biosynthetic process
GO:0016024 CDP-diacylglycerol biosynthetic process
GO:0019432 triglyceride biosynthetic process
GO:0044255 cellular lipid metabolic process
GO:0044281 small molecule metabolic process
GO:0046474 glycerophospholipid biosynthetic process
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Metabolism of lipids and lipoproteins pathway
Glycerophospholipid biosynthesis pathway
Triglyceride Biosynthesis pathway
Synthesis of PA pathway
Phospholipid metabolism pathway
Fatty acid, triacylglycerol, and ketone body metabolism pathway
Metabolism pathway
KEGG
Glycerolipid metabolism pathway
Glycerophospholipid metabolism pathway
Fat digestion and absorption pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt O15120
TrEMBL A0A024R8I7 Q8WUW2
UniProt Splice Variant
Entrez Gene 10555
UniGene Hs.320151
RefSeq NM_001012727 NM_006412
HUGO HGNC:325
OMIM 603100
CCDS CCDS7003 CCDS35181
HPRD 04373
IMGT
EMBL AF000237 AF011374 AL590226 BC000026 BC004529 BC019292 CH471090 U56418
GenPept AAB58776 AAB64299 AAC51649 AAH00026 AAH04529 AAH19292 CAH71722 CAH71723 EAW88249 EAW88250 EAW88251
RNA Seq Atlas 10555