InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: AGPAT2

Summary

InnateDB Protein

IDBP-92548.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AGPAT2

Protein Name

1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta)

Synonyms

1-AGPAT2; BSCL; BSCL1; LPAAB; LPAAT-beta;

Species

Homo sapiens

Ensembl Protein

ENSP00000360761

InnateDB Gene

IDBG-92546 (AGPAT2)

Protein Structure

UniProt Annotation

Function

Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. {ECO:0000269PubMed:15629135, ECO:0000269PubMed:21873652, ECO:0000269PubMed:9242711}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000269PubMed:21873652}; Multi-pass membrane protein {ECO:0000269PubMed:21873652}.

Disease Associations

Congenital generalized lipodystrophy 1 (CGL1) [MIM:608594]: An autosomal recessive disorder characterized by a near complete absence of adipose tissue, extreme insulin resistance, hypertriglyceridemia, hepatic steatosis and early onset of diabetes. {ECO:0000269PubMed:11967537}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Expressed predominantly in adipose tissue, pancreas and liver. {ECO:0000269PubMed:21873652}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003841	1-acylglycerol-3-phosphate O-acyltransferase activity
GO:0016746	transferase activity, transferring acyl groups

Biological Process

GO:0001819	positive regulation of cytokine production
GO:0001961	positive regulation of cytokine-mediated signaling pathway
GO:0006644	phospholipid metabolic process
GO:0006654	phosphatidic acid biosynthetic process
GO:0008152	metabolic process
GO:0008544	epidermis development
GO:0008654	phospholipid biosynthetic process
GO:0016024	CDP-diacylglycerol biosynthetic process
GO:0019432	triglyceride biosynthetic process
GO:0044255	cellular lipid metabolic process
GO:0044281	small molecule metabolic process
GO:0046474	glycerophospholipid biosynthetic process