Homo sapiens Gene: IL9R
Summary
InnateDB Gene IDBG-92623.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IL9R
Gene Name interleukin 9 receptor
Synonyms CD129; IL-9R;
Species Homo sapiens
Ensembl Gene ENSG00000124334
Encoded Proteins
interleukin 9 receptor
interleukin 9 receptor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a cytokine receptor that specifically mediates the biological effects of interleukin 9 (IL9). The functional IL9 receptor complex requires this protein as well as the interleukin 2 receptor, gamma (IL2RG), a common gamma subunit shared by the receptors of many different cytokines. The ligand binding of this receptor leads to the activation of various JAK kinases and STAT proteins, which connect to different biologic responses. This gene is located at the pseudoautosomal regions of X and Y chromosomes. Genetic studies suggested an association of this gene with the development of asthma. Multiple pseudogenes on chromosome 9, 10, 16, and 18 have been described. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome X:155997581-156010817
Strand Forward strand
Band q28
Transcripts
ENST00000244174 ENSP00000244174
ENST00000369423 ENSP00000358431
ENST00000489233
ENST00000483543
ENST00000494962
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
Experimentally validated
Total 13 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004896 cytokine receptor activity
GO:0004919 interleukin-9 receptor activity
GO:0005515 protein binding
GO:0019983 interleukin-9 binding
Biological Process
GO:0007165 signal transduction
GO:0008283 cell proliferation
GO:0019221 cytokine-mediated signaling pathway
GO:0030307 positive regulation of cell growth
GO:0038113 interleukin-9-mediated signaling pathway
GO:0045087 innate immune response
Cellular Component
GO:0005615 extracellular space
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
Orthologs
No orthologs found for this gene
Pathways
NETPATH
IL9 pathway
REACTOME
KEGG
Cytokine-cytokine receptor interaction pathway
Jak-STAT signaling pathway pathway
Hematopoietic cell lineage pathway
INOH
JAK STAT pathway and regulation pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q01113
TrEMBL I6L9D8
UniProt Splice Variant
Entrez Gene 3581
UniGene Hs.406228 Hs.720843
RefSeq NM_002186 NM_176786
HUGO HGNC:6030
OMIM 300007
CCDS CCDS14771 CCDS59180
HPRD
IMGT
EMBL AJ271736 AY071830 BC051337 CH471247 L39064 M84747 S71404 S71420
GenPept AAA58679 AAB30844 AAC29513 AAD14081 AAH51337 AAL55435 CAB96817 EAW55884
RNA Seq Atlas 3581