Version 5.4
Homo sapiens Gene: NBL1
Summary
InnateDB Gene IDBG-92720.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NBL1
Gene Name neuroblastoma, suppression of tumorigenicity 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000158747
Encoded Proteins
IDBP-92722
neuroblastoma, suppression of tumorigenicity 1
IDBP-92724
neuroblastoma, suppression of tumorigenicity 1
IDBP-373423
neuroblastoma, suppression of tumorigenicity 1
IDBP-373432
neuroblastoma, suppression of tumorigenicity 1
IDBP-373437
neuroblastoma, suppression of tumorigenicity 1
IDBP-373442
neuroblastoma, suppression of tumorigenicity 1
IDBP-373443
neuroblastoma, suppression of tumorigenicity 1
IDBP-373446
neuroblastoma, suppression of tumorigenicity 1
IDBP-591078
neuroblastoma, suppression of tumorigenicity 1
IDBP-807314
neuroblastoma 1, DAN family BMP antagonist
IDBP-807315
neuroblastoma 1, DAN family BMP antagonist
IDBP-807316
neuroblastoma 1, DAN family BMP antagonist
IDBP-807318
neuroblastoma 1, DAN family BMP antagonist
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This locus represents naturally occurring read-through transcription between the neighboring chromosome 1 open reading frame 151 (GeneID 440574) and neuroblastoma suppressor of tumorigenicity 1 (GeneID 4681) genes on chromosome 1. The read-through transcripts produce at least two proteins, each of which share identity with proteins translated from the downstream neuroblastoma suppressor of tumorigenicity 1 locus. [provided by RefSeq, Feb 2011] This gene product is the founding member of the evolutionarily conserved CAN (Cerberus and DAN) family of proteins, which contain a domain resembling the CTCK (C-terminal cystine knot-like) motif found in a number of signaling molecules. These proteins are secreted, and act as BMP (bone morphogenetic protein) antagonists by binding to BMPs and preventing them from interacting with their receptors. They may thus play an important role during growth and development. Alternatively spliced transcript variants have been identified for this gene. Read-through transcripts between this locus and the upstream chromosome 1 open reading frame 151 locus (GeneID 440574) have been observed.[provided by RefSeq, Feb 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:19640554-19658456
Strand Forward strand
Band p36.13
Transcripts
ENST00000375136 ENSP00000364278
ENST00000289749 ENSP00000289749
ENST00000428975 ENSP00000412419
ENST00000451758 ENSP00000390607
ENST00000439664 ENSP00000399333
ENST00000425400 ENSP00000400250
ENST00000439278 ENSP00000391858
ENST00000427894 ENSP00000394079
ENST00000548815 ENSP00000449007
ENST00000622566 ENSP00000480391
ENST00000621723 ENSP00000478885
ENST00000618761 ENSP00000483061
ENST00000615215 ENSP00000478223
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0016015 morphogen activity
GO:0036122 BMP binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0007399 nervous system development
GO:0030514 negative regulation of BMP signaling pathway
GO:0035582 sequestering of BMP in extracellular matrix
GO:0038098 sequestering of BMP from receptor via BMP binding
GO:0045666 positive regulation of neuron differentiation
GO:0048263 determination of dorsal identity
GO:0048812 neuron projection morphogenesis
GO:0090027 negative regulation of monocyte chemotaxis
Cellular Component
GO:0005615 extracellular space
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000041120
View Gene Order
ENSBTAG00000005140
Not yet available
Cross-References
SwissProt
TrEMBL E5RFZ1
UniProt Splice Variant
Entrez Gene 4681
UniGene Hs.654502
RefSeq NM_001204084 NM_001204085 NM_001204086 NM_001278164 NM_001278165 NM_001278166 NM_005380 NM_182744
HUGO HGNC:7650
OMIM 600613
CCDS CCDS196 CCDS41278 CCDS72720
HPRD 09001
IMGT
EMBL AL031727
GenPept
RNA Seq Atlas 100532736 4681

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca