InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NBL1

Summary

InnateDB Protein

IDBP-92724.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NBL1

Protein Name

neuroblastoma, suppression of tumorigenicity 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000289749

InnateDB Gene

IDBG-92720 (NBL1)

Protein Structure

UniProt Annotation

Function

Possible candidate as a tumor suppressor gene of neuroblastoma. May play an important role in preventing cells from entering the final stage (G1/S) of the transformation process.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Most abundant in normal lung and meningioma.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0016015	morphogen activity
GO:0036122	BMP binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0007399	nervous system development
GO:0030514	negative regulation of BMP signaling pathway
GO:0035582	sequestering of BMP in extracellular matrix
GO:0038098	sequestering of BMP from receptor via BMP binding
GO:0045666	positive regulation of neuron differentiation
GO:0048263	determination of dorsal identity
GO:0048812	neuron projection morphogenesis
GO:0090027	negative regulation of monocyte chemotaxis