Homo sapiens Gene: HTR6
Summary
InnateDB Gene IDBG-92735.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HTR6
Gene Name 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled
Synonyms 5-HT6; 5-HT6R;
Species Homo sapiens
Ensembl Gene ENSG00000158748
Encoded Proteins
5-hydroxytryptamine (serotonin) receptor 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein that belongs to the seven-transmembrane G protein-coupled receptor family of proteins. The encoded protein couples with the Gs alpha subunit and stimulates adenylate cyclase to activate the cyclic AMP-dependent signaling pathway. This receptor is thought to regulate cholinergic neuronal transmission in the brain. Several antidepressants and antipsychotic drugs have a high affinity for this receptor. [provided by RefSeq, Aug 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:19665287-19679562
Strand Forward strand
Band p36.13
Transcripts
ENST00000289753 ENSP00000289753
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
GO:0004969 histamine receptor activity
GO:0004993 serotonin receptor activity
GO:0005515 protein binding
Biological Process
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007268 synaptic transmission
GO:0007420 brain development
GO:0007612 learning
GO:0014050 negative regulation of glutamate secretion
GO:0014053 negative regulation of gamma-aminobutyric acid secretion
GO:0014054 positive regulation of gamma-aminobutyric acid secretion
GO:0014058 negative regulation of acetylcholine secretion, neurotransmission
GO:0032355 response to estradiol
GO:0033603 positive regulation of dopamine secretion
GO:0042493 response to drug
GO:0060291 long-term synaptic potentiation
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005929 cilium
GO:0016021 integral component of membrane
GO:0030425 dendrite
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
G alpha (s) signalling events pathway
Class A/1 (Rhodopsin-like receptors) pathway
Signaling by GPCR pathway
Serotonin receptors pathway
Amine ligand-binding receptors pathway
Signal Transduction pathway
GPCR downstream signaling pathway
GPCR ligand binding pathway
KEGG
Calcium signaling pathway pathway
Neuroactive ligand-receptor interaction pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt P50406
TrEMBL
UniProt Splice Variant
Entrez Gene 3362
UniGene Hs.22180
RefSeq NM_000871
HUGO HGNC:5301
OMIM 601109
CCDS CCDS197
HPRD 03066
IMGT
EMBL AL031727 AY429105 BC074995 BC074996 CH471134 L41147 Z49119
GenPept AAA92622 AAH74995 AAH74996 AAR07900 CAA88929 CAI19020 EAW94896
RNA Seq Atlas 3362