InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: HTR6

Summary

InnateDB Gene

IDBG-92735.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HTR6

Gene Name

5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled

Synonyms

5-HT6; 5-HT6R

Species

Homo sapiens

Ensembl Gene

ENSG00000158748

Encoded Proteins

IDBP-92737

5-hydroxytryptamine (serotonin) receptor 6

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a protein that belongs to the seven-transmembrane G protein-coupled receptor family of proteins. The encoded protein couples with the Gs alpha subunit and stimulates adenylate cyclase to activate the cyclic AMP-dependent signaling pathway. This receptor is thought to regulate cholinergic neuronal transmission in the brain. Several antidepressants and antipsychotic drugs have a high affinity for this receptor. [provided by RefSeq, Aug 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:19665287-19679562

Strand

Forward strand

Band

p36.13

Transcripts

ENST00000289753

ENSP00000289753

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004969	histamine receptor activity
GO:0004993	serotonin receptor activity
GO:0005515	protein binding

Biological Process

GO:0007186	G-protein coupled receptor signaling pathway
GO:0007187	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007268	synaptic transmission
GO:0007420	brain development
GO:0007612	learning
GO:0014050	negative regulation of glutamate secretion
GO:0014053	negative regulation of gamma-aminobutyric acid secretion
GO:0014054	positive regulation of gamma-aminobutyric acid secretion
GO:0014058	negative regulation of acetylcholine secretion, neurotransmission
GO:0032355	response to estradiol
GO:0033603	positive regulation of dopamine secretion
GO:0042493	response to drug
GO:0060291	long-term synaptic potentiation

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0005929	cilium
GO:0016021	integral component of membrane
GO:0030425	dendrite

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000028747

View Gene Order

ENSBTAG00000007996

Not yet available

Pathways

NETPATH

REACTOME

REACT_19327

G alpha (s) signalling events pathway

REACT_17064

Serotonin receptors pathway

REACT_16983

Amine ligand-binding receptors pathway

REACT_14828

Class A/1 (Rhodopsin-like receptors) pathway

REACT_14797

Signaling by GPCR pathway

REACT_111102

Signal Transduction pathway

REACT_19184

GPCR downstream signaling pathway

REACT_21340

GPCR ligand binding pathway

KEGG

hsa04080

Neuroactive ligand-receptor interaction pathway

hsa04020

Calcium signaling pathway pathway

INOH

PID NCI

Cross-References

SwissProt

P50406

TrEMBL

UniProt Splice Variant

Entrez Gene

3362

UniGene

Hs.22180

RefSeq

NM_000871

HUGO

HGNC:5301

OMIM

601109

CCDS

CCDS197

HPRD

03066

IMGT

EMBL

AL031727 AY429105 BC074995 BC074996 CH471134 L41147 Z49119

GenPept

AAA92622 AAH74995 AAH74996 AAR07900 CAA88929 CAI19020 EAW94896

RNA Seq Atlas

3362