InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HTR6

Summary

InnateDB Protein

IDBP-92737.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HTR6

Protein Name

5-hydroxytryptamine (serotonin) receptor 6

Synonyms

5-HT6; 5-HT6R;

Species

Homo sapiens

Ensembl Protein

ENSP00000289753

InnateDB Gene

IDBG-92735 (HTR6)

Protein Structure

UniProt Annotation

Function

This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. It has a high affinity for tricyclic psychotropic drugs.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Expressed in several human brain regions, most prominently in the caudate nucleus.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004969	histamine receptor activity
GO:0004993	serotonin receptor activity
GO:0005515	protein binding

Biological Process

GO:0007186	G-protein coupled receptor signaling pathway
GO:0007187	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007268	synaptic transmission
GO:0007420	brain development
GO:0007612	learning
GO:0014050	negative regulation of glutamate secretion
GO:0014053	negative regulation of gamma-aminobutyric acid secretion
GO:0014054	positive regulation of gamma-aminobutyric acid secretion
GO:0014058	negative regulation of acetylcholine secretion, neurotransmission
GO:0032355	response to estradiol
GO:0033603	positive regulation of dopamine secretion
GO:0042493	response to drug
GO:0060291	long-term synaptic potentiation