Version 5.4
Homo sapiens Gene: ENTPD2
Summary
InnateDB Gene IDBG-93039.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ENTPD2
Gene Name ectonucleoside triphosphate diphosphohydrolase 2
Synonyms CD39L1; NTPDase-2
Species Homo sapiens
Ensembl Gene ENSG00000054179
Encoded Proteins
IDBP-93041
ectonucleoside triphosphate diphosphohydrolase 2
IDBP-93043
ectonucleoside triphosphate diphosphohydrolase 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is the type 2 enzyme of the ecto-nucleoside triphosphate diphosphohydrolase family (E-NTPDase). E-NTPDases are a family of ecto-nucleosidases that hydrolyze 5'-triphosphates. This ecto-ATPase is an integral membrane protein. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is the type 2 enzyme of the ecto-nucleoside triphosphate diphosphohydrolase family (E-NTPDase). E-NTPDases are a family of ecto-nucleosidases that hydrolyze 5\'-triphosphates. This ecto-ATPase is an integral membrane protein. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:137048098-137054045
Strand Reverse strand
Band q34.3
Transcripts
ENST00000355097 ENSP00000347213
ENST00000312665 ENSP00000312494
ENST00000460614
ENST00000469106
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0017110 nucleoside-diphosphatase activity
GO:0017111 nucleoside-triphosphatase activity
Biological Process
GO:0007186 G-protein coupled receptor signaling pathway
GO:0009181 purine ribonucleoside diphosphate catabolic process
GO:0030168 platelet activation
Cellular Component
GO:0005605 basal lamina
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000015085
View Gene Order
ENSBTAG00000048125
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa00230
Purine metabolism pathway
INOH
INOH website
Purine nucleotides nucleosides metabolism pathway
PID NCI
Cross-References
SwissProt Q9Y5L3
TrEMBL
UniProt Splice Variant
Entrez Gene 954
UniGene Hs.123036
RefSeq NM_203468 NM_001246
HUGO HGNC:3364
OMIM 602012
CCDS CCDS7026 CCDS7025
HPRD 03600
IMGT
EMBL AF144748 AL807752 BC035738 CH471090 EF495152 U91510
GenPept AAB81013 AAD40239 AAH35738 ABP58644 CAI12777 EAW88336 EAW88337
RNA Seq Atlas 954

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca