Homo sapiens Gene: MAN1B1
Summary
InnateDB Gene IDBG-93060.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MAN1B1
Gene Name mannosidase, alpha, class 1B, member 1
Synonyms ERMAN1; MANA-ER; MRT15;
Species Homo sapiens
Ensembl Gene ENSG00000177239
Encoded Proteins
mannosidase, alpha, class 1B, member 1
mannosidase, alpha, class 1B, member 1
mannosidase, alpha, class 1B, member 1
mannosidase, alpha, class 1B, member 1
mannosidase, alpha, class 1B, member 1
mannosidase, alpha, class 1B, member 1
mannosidase, alpha, class 1B, member 1
mannosidase, alpha, class 1B, member 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes an enzyme belonging to the glycosyl hydrolase 47 family. This enzyme functions in N-glycan biosynthesis, and is a class I alpha-1,2-mannosidase that specifically converts Man9GlcNAc to Man8GlcNAc isomer B. It is required for N-glycan trimming to Man5-6GlcNAc2 in the endoplasmic-reticulum-associated degradation pathway. Mutations in this gene cause autosomal-recessive intellectual disability. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 11. [provided by RefSeq, Dec 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:137086927-137109187
Strand Forward strand
Band q34.3
Transcripts
ENST00000371589 ENSP00000360645
ENST00000371587 ENSP00000483132
ENST00000474902
ENST00000480100
ENST00000475449 ENSP00000448658
ENST00000544448 ENSP00000444966
ENST00000535144 ENSP00000441398
ENST00000545539 ENSP00000440314
ENST00000542372 ENSP00000444189
ENST00000545096
ENST00000540346
ENST00000536349
ENST00000540391
ENST00000535028
ENST00000536268
ENST00000550113 ENSP00000450147
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006457 protein folding
GO:0006487 protein N-linked glycosylation
GO:0008152 metabolic process
GO:0009311 oligosaccharide metabolic process
GO:0018279 protein N-linked glycosylation via asparagine
GO:0030433 ER-associated ubiquitin-dependent protein catabolic process
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0044322 endoplasmic reticulum quality control compartment
Orthologs
Species
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Pathways
NETPATH
REACTOME
Calnexin/calreticulin cycle pathway
Post-translational protein modification pathway
Asparagine N-linked glycosylation pathway
Metabolism of proteins pathway
ER Quality Control Compartment (ERQC) pathway
N-glycan trimming in the ER and Calnexin/Calreticulin cycle pathway
KEGG
N-Glycan biosynthesis pathway
Protein processing in endoplasmic reticulum pathway
INOH
PID BIOCARTA
Er associated degradation (erad) pathway [Biocarta view]
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.715863
RefSeq NM_016219 XM_006716945
HUGO
OMIM
CCDS CCDS7029
HPRD 05068
IMGT
EMBL
GenPept
RNA Seq Atlas