Version 5.4
Homo sapiens Gene: AFAP1
Summary
InnateDB Gene IDBG-9307.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AFAP1
Gene Name actin filament associated protein 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000196526
Encoded Proteins
IDBP-9309
actin filament associated protein 1
IDBP-9311
actin filament associated protein 1
IDBP-9313
actin filament associated protein 1
IDBP-362140
actin filament associated protein 1
IDBP-811739
actin filament associated protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a Src binding partner. It may represent a potential modulator of actin filament integrity in response to cellular signals, and may function as an adaptor protein by linking Src family members and/or other signaling proteins to actin filaments. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:7758714-7939926
Strand Reverse strand
Band p16.1
Transcripts
ENST00000360265 ENSP00000353402
ENST00000358461 ENSP00000351245
ENST00000382543 ENSP00000371983
ENST00000420658 ENSP00000410689
ENST00000505447
ENST00000513842
ENST00000508415
ENST00000513856
ENST00000614385 ENSP00000483962
ENST00000612691
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 8 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
Biological Process
Cellular Component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000029094
View Gene Order
ENSBTAG00000012464
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.529369
RefSeq NM_001134647 NM_198595 XM_006713908 XM_006713909 XM_006713910
HUGO
OMIM
CCDS CCDS3397 CCDS47010
HPRD 09747
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca