Version 5.4
Mus musculus Gene: Afap1
Summary
InnateDB Gene IDBG-157728.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Afap1
Gene Name actin filament associated protein 1
Synonyms 2600003E23Rik; 9630044L16Rik; Afap; AI848729; mKIAA3018
Species Mus musculus
Ensembl Gene ENSMUSG00000029094
Encoded Proteins
IDBP-157730
actin filament associated protein 1
IDBP-540467
actin filament associated protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000196526:
The protein encoded by this gene is a Src binding partner. It may represent a potential modulator of actin filament integrity in response to cellular signals, and may function as an adaptor protein by linking Src family members and/or other signaling proteins to actin filaments. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:35893319-36003923
Strand Forward strand
Band B3
Transcripts
ENSMUST00000064571 ENSMUSP00000067779
ENSMUST00000146300
ENSMUST00000141824 ENSMUSP00000119364
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0017124 SH3 domain binding
Biological Process
Cellular Component
GO:0005737 cytoplasm
GO:0005925 focal adhesion
GO:0015629 actin cytoskeleton
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000196526
View Gene Order
ENSBTAG00000012464
Not yet available
Cross-References
SwissProt Q80YS6
TrEMBL E9Q8X9 Q9CT56
UniProt Splice Variant
Entrez Gene 70292
UniGene Mm.125167 Mm.411853 Mm.473806
RefSeq NM_027373 XM_006504099
OMIM
CCDS CCDS19236
HPRD
IMGT
MGI ID MGI:1917542
MGI Symbol Afap1
EMBL AC127275 AC141898 AK011153 AK129483 AK147706 AK148000 AK161385 BC050814
GenPept AAH50814 BAB27434 BAC98293 BAE28086 BAE28280 BAE36364
RNA Seq Atlas 70292

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca