Homo sapiens Gene: EBF3
Summary
InnateDB Gene IDBG-93214.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EBF3
Gene Name early B-cell factor 3
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000108001
Encoded Proteins
early B-cell factor 3
early B-cell factor 3
early B-cell factor 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the early B-cell factor (EBF) family of DNA binding transcription factors. EBF proteins are involved in B-cell differentiation, bone development and neurogenesis, and may also function as tumor suppressors. The encoded protein inhibits cell survival through the regulation of genes involved in cell cycle arrest and apoptosis, and aberrant methylation or deletion of this gene may play a role in multiple malignancies including glioblastoma multiforme and gastric carcinoma. [provided by RefSeq, Sep 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:129835283-129963841
Strand Reverse strand
Band q26.3
Transcripts
ENST00000355311 ENSP00000347463
ENST00000368648 ENSP00000357637
ENST00000440978 ENSP00000387543
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0046872 metal ion binding
GO:0046983 protein dimerization activity
Biological Process
GO:0006351 transcription, DNA-templated
GO:0007275 multicellular organismal development
GO:0045893 positive regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Cross-References
SwissProt Q9H4W6
TrEMBL Q658Y5
UniProt Splice Variant
Entrez Gene 253738
UniGene Hs.205433 Hs.591374 Hs.713683
RefSeq NM_001005463 XM_005252668
HUGO HGNC:19087
OMIM 607407
CCDS CCDS31314
HPRD
IMGT
EMBL AL354950 AL832828 BC126130 BC130479 CH471066
GenPept AAI26131 AAI30480 CAH56225 CAI12792 CAI12793 EAW49160
RNA Seq Atlas 253738