Homo sapiens Gene: IGFALS
Summary
InnateDB Gene IDBG-9328.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IGFALS
Gene Name insulin-like growth factor binding protein, acid labile subunit
Synonyms ACLSD; ALS;
Species Homo sapiens
Ensembl Gene ENSG00000099769
Encoded Proteins
insulin-like growth factor binding protein, acid labile subunit
insulin-like growth factor binding protein, acid labile subunit
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a serum protein that binds insulin-like growth factors, increasing their half-life and their vascular localization. Production of the encoded protein, which contains twenty leucine-rich repeats, is stimulated by growth hormone. Defects in this gene are a cause of acid-labile subunit deficiency, which maifests itself in a delayed and slow puberty. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:1790413-1794971
Strand Reverse strand
Band p13.3
Transcripts
ENST00000215539 ENSP00000215539
ENST00000415638 ENSP00000416683
ENST00000568221 ENSP00000456923
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005520 insulin-like growth factor binding
Biological Process
GO:0007155 cell adhesion
GO:0007165 signal transduction
GO:0044267 cellular protein metabolic process
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) pathway
Metabolism of proteins pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.839
RefSeq NM_001146006 NM_004970
HUGO
OMIM
CCDS CCDS10446 CCDS53982
HPRD 03290
IMGT
EMBL
GenPept
RNA Seq Atlas