Homo sapiens Gene: NOXA1
Summary
InnateDB Gene IDBG-93355.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NOXA1
Gene Name NADPH oxidase activator 1
Synonyms NY-CO-31; p51NOX; SDCCAG31;
Species Homo sapiens
Ensembl Gene ENSG00000188747
Encoded Proteins
NADPH oxidase activator 1
NADPH oxidase activator 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
NOXA1 together with NADPH oxidase organizer 1 (NOXO1) are key regulatory subunits of the NADPH oxidase NOX1, the activity of which is regulated through MAP kinase (MAPK), protein kinase C (PKC), and protein kinase A (PKA)-dependent phosphorylation on Ser-282 and Ser-172 of NOXA1.
Entrez Gene
Summary This gene encodes a protein which activates NADPH oxidases, enzymes which catalyze a reaction generating reactive oxygen species. The encoded protein contains four N-terminal tetratricopeptide domains and a C-terminal Src homology 3 domain. Interaction between the encoded protein and proteins in the oxidase regulatory complex occur via the tetratricopeptide domains. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:137423350-137434406
Strand Forward strand
Band q34.3
Transcripts
ENST00000341349 ENSP00000342848
ENST00000392815 ENSP00000376562
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
Experimentally validated
Total 19 [view]
Protein-Protein 19 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0016176 superoxide-generating NADPH oxidase activator activity
GO:0017124 SH3 domain binding
GO:0019899 enzyme binding
GO:0048365 Rac GTPase binding
Biological Process
GO:0006801 superoxide metabolic process
GO:0010310 regulation of hydrogen peroxide metabolic process
GO:0043085 positive regulation of catalytic activity
GO:0045087 innate immune response (InnateDB)
GO:0060263 regulation of respiratory burst
Cellular Component
GO:0005737 cytoplasm
GO:0043020 NADPH oxidase complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
INOH
PID BIOCARTA
PID NCI
RAC1 signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.495554
RefSeq NM_001256067 NM_001256068 NM_006647
HUGO
OMIM
CCDS CCDS59157 CCDS7042
HPRD 17644
IMGT
EMBL
GenPept
RNA Seq Atlas