Version 5.4
Homo sapiens Gene: NOXA1
Summary
InnateDB Gene IDBG-93355.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NOXA1
Gene Name NADPH oxidase activator 1
Synonyms NY-CO-31; p51NOX; SDCCAG31
Species Homo sapiens
Ensembl Gene ENSG00000188747
Encoded Proteins
IDBP-93357
NADPH oxidase activator 1
IDBP-244889
NADPH oxidase activator 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 20110267
NOXA1 together with NADPH oxidase organizer 1 (NOXO1) are key regulatory subunits of the NADPH oxidase NOX1, the activity of which is regulated through MAP kinase (MAPK), protein kinase C (PKC), and protein kinase A (PKA)-dependent phosphorylation on Ser-282 and Ser-172 of NOXA1.
Entrez Gene
Summary This gene encodes a protein which activates NADPH oxidases, enzymes which catalyze a reaction generating reactive oxygen species. The encoded protein contains four N-terminal tetratricopeptide domains and a C-terminal Src homology 3 domain. Interaction between the encoded protein and proteins in the oxidase regulatory complex occur via the tetratricopeptide domains. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:137423350-137434406
Strand Forward strand
Band q34.3
Transcripts
ENST00000341349 ENSP00000342848
ENST00000392815 ENSP00000376562
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
Experimentally validated
Total 19 [view]
Protein-Protein 19 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0016176 superoxide-generating NADPH oxidase activator activity
GO:0017124 SH3 domain binding
GO:0019899 enzyme binding
GO:0048365 Rac GTPase binding
Biological Process
GO:0006801 superoxide metabolic process
GO:0010310 regulation of hydrogen peroxide metabolic process
GO:0043085 positive regulation of catalytic activity
GO:0045087 innate immune response (InnateDB)
GO:0060263 regulation of respiratory burst
Cellular Component
GO:0005737 cytoplasm
GO:0043020 NADPH oxidase complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000036805
View Gene Order
ENSBTAG00000012121
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
rac1_pathway
RAC1 signaling pathway
Cross-References
SwissProt Q86UR1
TrEMBL
UniProt Splice Variant
Entrez Gene 10811
UniGene Hs.495554
RefSeq NM_001256068 NM_001256067 NM_006647
HUGO HGNC:10668
OMIM 611255
CCDS CCDS59157 CCDS7042
HPRD 17644
IMGT
EMBL AB095031 AF039697 AY255769 AY927790 AY927791 BC041594 BC110840 BX322799
GenPept AAC18046 AAH41594 AAI10841 AAP13480 AAY16126 AAY16127 BAC76710 CAM24776
RNA Seq Atlas 10811

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca