Homo sapiens Gene: CACNA1B
Summary
InnateDB Gene IDBG-93621.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CACNA1B
Gene Name calcium channel, voltage-dependent, N type, alpha 1B subunit
Synonyms BIII; CACNL1A5; CACNN; Cav2.2;
Species Homo sapiens
Ensembl Gene ENSG00000148408
Encoded Proteins
calcium channel, voltage-dependent, N type, alpha 1B subunit
calcium channel, voltage-dependent, N type, alpha 1B subunit
calcium channel, voltage-dependent, N type, alpha 1B subunit
calcium channel, voltage-dependent, N type, alpha 1B subunit
calcium channel, voltage-dependent, N type, alpha 1B subunit
calcium channel, voltage-dependent, N type, alpha 1B subunit
calcium channel, voltage-dependent, N type, alpha 1B subunit
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is the pore-forming subunit of an N-type voltage-dependent calcium channel, which controls neurotransmitter release from neurons. The encoded protein forms a complex with alpha-2, beta, and delta subunits to form the high-voltage activated channel. This channel is sensitive to omega-conotoxin-GVIA and omega-agatoxin-IIIA but insensitive to dihydropyridines. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:137877789-138124624
Strand Forward strand
Band q34.3
Transcripts
ENST00000371372 ENSP00000360423
ENST00000277551 ENSP00000277551
ENST00000371363 ENSP00000360414
ENST00000371357 ENSP00000360408
ENST00000277549 ENSP00000277549
ENST00000371355 ENSP00000360406
ENST00000413253 ENSP00000413042
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 11 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005216 ion channel activity
GO:0005245 voltage-gated calcium channel activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008022 protein C-terminus binding
GO:0008331 high voltage-gated calcium channel activity
Biological Process
GO:0006810 transport
GO:0006811 ion transport
GO:0006816 calcium ion transport
GO:0007268 synaptic transmission
GO:0007269 neurotransmitter secretion
GO:0007626 locomotory behavior
GO:0008016 regulation of heart contraction
GO:0008217 regulation of blood pressure
GO:0034220 ion transmembrane transport
GO:0034765 regulation of ion transmembrane transport
GO:0048265 response to pain
GO:0051899 membrane depolarization
GO:0051924 regulation of calcium ion transport
GO:0055085 transmembrane transport
GO:0070509 calcium ion import
GO:0070588 calcium ion transmembrane transport
GO:0086010 membrane depolarization during action potential
Cellular Component
GO:0005886 plasma membrane
GO:0005891 voltage-gated calcium channel complex
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030425 dendrite
GO:0043025 neuronal cell body
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Neuronal System pathway
Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels pathway
Transmission across Chemical Synapses pathway
KEGG
MAPK signaling pathway pathway
Calcium signaling pathway pathway
Taste transduction pathway
Type II diabetes mellitus pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q00975
TrEMBL Q9HAT4 Q9HAT5 Q9HBG2 Q9HBG3 Q9HBH4 Q9HBI3
UniProt Splice Variant
Entrez Gene 774
UniGene Hs.495522
RefSeq NM_000718 NM_001243812
HUGO HGNC:1389
OMIM 601012
CCDS CCDS59522 CCDS59523
HPRD 03005
IMGT
EMBL AF233289 AF237470 AF238295 AF239237 AF245659 AF245660 AF247811 AF302779 AF302780 AF302782 AL591424 AL772363 M94172 M94173 U76666
GenPept AAA51897 AAA51898 AAC51138 AAG13644 AAG13647 AAG13648 AAG13650 AAG14396 AAG14397 CAI17144 CAI40687
RNA Seq Atlas 774