InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: CACNA1B

Summary

InnateDB Gene

IDBG-640876.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CACNA1B

Gene Name

voltage-dependent N-type calcium channel subunit alpha-1B

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000007882

Encoded Proteins

IDBP-693204

voltage-dependent N-type calcium channel subunit alpha-1B

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000148408:
The protein encoded by this gene is the pore-forming subunit of an N-type voltage-dependent calcium channel, which controls neurotransmitter release from neurons. The encoded protein forms a complex with alpha-2, beta, and delta subunits to form the high-voltage activated channel. This channel is sensitive to omega-conotoxin-GVIA and omega-agatoxin-IIIA but insensitive to dihydropyridines. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:105182214-105394448

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000048983

ENSBTAP00000045932

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005244	voltage-gated ion channel activity
GO:0005245	voltage-gated calcium channel activity
GO:0005262	calcium channel activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0008331	high voltage-gated calcium channel activity

Biological Process

GO:0006810	transport
GO:0006811	ion transport
GO:0006816	calcium ion transport
GO:0007268	synaptic transmission
GO:0007269	neurotransmitter secretion
GO:0007626	locomotory behavior
GO:0008016	regulation of heart contraction
GO:0008217	regulation of blood pressure
GO:0034765	regulation of ion transmembrane transport
GO:0048265	response to pain
GO:0051924	regulation of calcium ion transport
GO:0055085	transmembrane transport
GO:0070509	calcium ion import
GO:0070588	calcium ion transmembrane transport
GO:0086010	membrane depolarization during action potential

Cellular Component

GO:0005886	plasma membrane
GO:0005891	voltage-gated calcium channel complex
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030425	dendrite
GO:0043025	neuronal cell body