Version 5.4
Homo sapiens Gene: ADAM8
Summary
InnateDB Gene IDBG-93642.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ADAM8
Gene Name ADAM metallopeptidase domain 8
Synonyms CD156; CD156a; MS2
Species Homo sapiens
Ensembl Gene ENSG00000151651
Encoded Proteins
IDBP-583226
ADAM metallopeptidase domain 8
IDBP-593467
ADAM metallopeptidase domain 8
IDBP-591423
ADAM metallopeptidase domain 8
IDBP-591899
ADAM metallopeptidase domain 8
IDBP-601292
ADAM metallopeptidase domain 8
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene may be involved in cell adhesion during neurodegeneration, and it is thought to be a target for allergic respiratory diseases, including asthma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:133262403-133276868
Strand Reverse strand
Band q26.3
Transcripts
ENST00000415217 ENSP00000453855
ENST00000445355 ENSP00000453302
ENST00000485491 ENSP00000453043
ENST00000468964
ENST00000463298
ENST00000486609 ENSP00000453735
ENST00000559018
ENST00000561175
ENST00000537099
ENST00000560135 ENSP00000452994
ENST00000559180
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004222 metalloendopeptidase activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
GO:0043621 protein self-association
GO:0050839 cell adhesion molecule binding
Biological Process
GO:0000902 cell morphogenesis
GO:0001525 angiogenesis
GO:0002523 leukocyte migration involved in inflammatory response
GO:0002675 positive regulation of acute inflammatory response
GO:0002693 positive regulation of cellular extravasation
GO:0006508 proteolysis
GO:0006954 inflammatory response
GO:0010954 positive regulation of protein processing
GO:0016337 single organismal cell-cell adhesion
GO:0022407 regulation of cell-cell adhesion
GO:0022617 extracellular matrix disassembly
GO:0030198 extracellular matrix organization
GO:0033089 positive regulation of T cell differentiation in thymus
GO:0035419 activation of MAPK activity involved in innate immune response
GO:0043524 negative regulation of neuron apoptotic process
GO:0045780 positive regulation of bone resorption
GO:0045785 positive regulation of cell adhesion
GO:0048247 lymphocyte chemotaxis
GO:0050714 positive regulation of protein secretion
GO:0050729 positive regulation of inflammatory response
GO:0051044 positive regulation of membrane protein ectodomain proteolysis
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051897 positive regulation of protein kinase B signaling
GO:0070245 positive regulation of thymocyte apoptotic process
GO:0071456 cellular response to hypoxia
GO:2000309 positive regulation of tumor necrosis factor (ligand) superfamily member 11 production
GO:2000391 positive regulation of neutrophil extravasation
GO:2000406 positive regulation of T cell migration
GO:2000415 positive regulation of fibronectin-dependent thymocyte migration
GO:2000418 positive regulation of eosinophil migration
Cellular Component
GO:0002102 podosome
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0009986 cell surface
GO:0032010 phagolysosome
GO:0032127 dense core granule membrane
GO:0042581 specific granule
GO:0070820 tertiary granule
GO:0071065 alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex
GO:0071133 alpha9-beta1 integrin-ADAM8 complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000025473
View Gene Order
ENSBTAG00000023832
Not yet available
Pathways
NETPATH
REACTOME
REACT_118779
Extracellular matrix organization pathway
REACT_118572
Degradation of the extracellular matrix pathway
KEGG
INOH
PID NCI
integrin_a9b1_pathway
Alpha9 beta1 integrin signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.501574
RefSeq NM_001109 NM_001164489 NM_001164490
HUGO
OMIM
CCDS CCDS31319 CCDS58102 CCDS58103
HPRD 03777
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca