InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ADAM8

Summary

InnateDB Protein

IDBP-583226.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ADAM8

Protein Name

ADAM metallopeptidase domain 8

Synonyms

CD156; CD156a; MS2;

Species

Homo sapiens

Ensembl Protein

ENSP00000453855

InnateDB Gene

IDBG-93642 (ADAM8)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004222	metalloendopeptidase activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008237	metallopeptidase activity
GO:0008270	zinc ion binding
GO:0043621	protein self-association
GO:0050839	cell adhesion molecule binding

Biological Process

GO:0000902	cell morphogenesis
GO:0001525	angiogenesis
GO:0002523	leukocyte migration involved in inflammatory response
GO:0002675	positive regulation of acute inflammatory response
GO:0006508	proteolysis
GO:0006954	inflammatory response
GO:0010954	positive regulation of protein processing
GO:0022407	regulation of cell-cell adhesion
GO:0022617	extracellular matrix disassembly
GO:0030198	extracellular matrix organization
GO:0033089	positive regulation of T cell differentiation in thymus
GO:0035419	activation of MAPK activity involved in innate immune response
GO:0043524	negative regulation of neuron apoptotic process
GO:0045780	positive regulation of bone resorption
GO:0045785	positive regulation of cell adhesion
GO:0048247	lymphocyte chemotaxis
GO:0050714	positive regulation of protein secretion
GO:0051044	positive regulation of membrane protein ectodomain proteolysis
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0051897	positive regulation of protein kinase B signaling
GO:0070245	positive regulation of thymocyte apoptotic process
GO:0071456	cellular response to hypoxia
GO:2000309	positive regulation of tumor necrosis factor (ligand) superfamily member 11 production
GO:2000391	positive regulation of neutrophil extravasation
GO:2000415	positive regulation of fibronectin-dependent thymocyte migration
GO:2000418	positive regulation of eosinophil migration

Cellular Component

GO:0002102	podosome
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0009986	cell surface
GO:0032010	phagolysosome
GO:0032127	dense core granule membrane
GO:0042581	specific granule
GO:0070820	tertiary granule
GO:0071065	alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex
GO:0071133	alpha9-beta1 integrin-ADAM8 complex

Protein Structure and Domains

PDB ID

InterPro

IPR000742 Epidermal growth factor-like domain
IPR001590 Peptidase M12B, ADAM/reprolysin
IPR001762 Blood coagulation inhibitor, Disintegrin
IPR002870 Peptidase M12B, propeptide
IPR006586 ADAM, cysteine-rich

PFAM

PF00008
PF01421
PF00200
PF01562
PF08516

PRINTS

PR00289

PIRSF

SMART

SM00181
SM00050
SM00608

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt