InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: EPHA8

Summary

InnateDB Gene

IDBG-93699.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EPHA8

Gene Name

EPH receptor A8

Synonyms

EEK; EK3; HEK3

Species

Homo sapiens

Ensembl Gene

ENSG00000070886

Encoded Proteins

IDBP-93701

EPH receptor A8

IDBP-93703

EPH receptor A8

IDBP-584819

EPH receptor A8

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. The protein encoded by this gene functions as a receptor for ephrin A2, A3 and A5 and plays a role in short-range contact-mediated axonal guidance during development of the mammalian nervous system. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:22563564-22603594

Strand

Forward strand

Band

p36.12

Transcripts

ENST00000166244	ENSP00000166244
ENST00000374644	ENSP00000363775
ENST00000538803	ENSP00000440274

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005003	ephrin receptor activity
GO:0005004	GPI-linked ephrin receptor activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468	protein phosphorylation
GO:0006929	substrate-dependent cell migration
GO:0007155	cell adhesion
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007411	axon guidance
GO:0016322	neuron remodeling
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0030155	regulation of cell adhesion
GO:0031175	neuron projection development
GO:0033628	regulation of cell adhesion mediated by integrin
GO:0043410	positive regulation of MAPK cascade
GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity
GO:0046777	protein autophosphorylation
GO:0048013	ephrin receptor signaling pathway

Cellular Component

GO:0005887	integral component of plasma membrane
GO:0031901	early endosome membrane
GO:0043005	neuron projection

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000028661

View Gene Order

ENSBTAG00000020102

Not yet available

Pathways

NETPATH

REACTOME

REACT_111045

Developmental Biology pathway

REACT_18266

Axon guidance pathway

REACT_228063

EPHA-mediated growth cone collapse pathway

REACT_228189

EPH-ephrin mediated repulsion of cells pathway

REACT_228170

EPH-Ephrin signaling pathway

KEGG

hsa04360

Axon guidance pathway

INOH

PID NCI

epha_fwdpathway

EPHA forward signaling

ephrina_ephapathway

EphrinA-EPHA pathway

Cross-References

SwissProt

P29322

TrEMBL

UniProt Splice Variant

Entrez Gene

2046

UniGene

Hs.283613

RefSeq

NM_001006943 NM_020526

HUGO

HGNC:3391

OMIM

176945

CCDS

CCDS225 CCDS30626

HPRD

IMGT

EMBL

AB040892 AL035703 BC038796 BC072417 X59291

GenPept

AAH38796 AAH72417 BAA95983 CAA41980 CAB81612 CAI22039

RNA Seq Atlas

2046