InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: EPHA8

Summary

InnateDB Protein

IDBP-584819.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EPHA8

Protein Name

EPH receptor A8

Synonyms

EEK; EK3; HEK3;

Species

Homo sapiens

Ensembl Protein

ENSP00000440274

InnateDB Gene

IDBG-93699 (EPHA8)

Protein Structure

UniProt Annotation

Function

Receptor tyrosine kinase which binds promiscuously GPI- anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. The GPI-anchored ephrin-A EFNA2, EFNA3, and EFNA5 are able to activate EPHA8 through phosphorylation. With EFNA5 may regulate integrin-mediated cell adhesion and migration on fibronectin substrate but also neurite outgrowth. During development of the nervous system plays also a role in axon guidance. Downstream effectors of the EPHA8 signaling pathway include FYN which promotes cell adhesion upon activation by EPHA8 and the MAP kinases in the stimulation of neurite outgrowth (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cell projection {ECO:0000250}. Early endosome membrane {ECO:0000250}. Note=Undergoes clathrin-mediated endocytosis upon EFNA5-binding and is targeted to early endosomes. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005004	GPI-linked ephrin receptor activity
GO:0005515	protein binding
GO:0005524	ATP binding

Biological Process

GO:0006929	substrate-dependent cell migration
GO:0007155	cell adhesion
GO:0007411	axon guidance
GO:0016322	neuron remodeling
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0030155	regulation of cell adhesion
GO:0031175	neuron projection development
GO:0033628	regulation of cell adhesion mediated by integrin
GO:0043410	positive regulation of MAPK cascade
GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity
GO:0046777	protein autophosphorylation
GO:0048013	ephrin receptor signaling pathway

Cellular Component

GO:0005887	integral component of plasma membrane
GO:0031901	early endosome membrane
GO:0043005	neuron projection

Protein Structure and Domains

PDB ID

InterPro

IPR001090 Ephrin receptor ligand binding domain
IPR003961 Fibronectin, type III
IPR008979 Galactose-binding domain-like
IPR009030 Insulin-like growth factor binding protein, N-terminal

PFAM

PF01404
PF00041
PF01108

PRINTS

PIRSF

SMART

SM00615
SM00060

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P29322