Version 5.4
Homo sapiens Gene: CNR1
Summary
InnateDB Gene IDBG-94226.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CNR1
Gene Name cannabinoid receptor 1 (brain)
Synonyms CANN6; CB-R; CB1; CB1A; CB1K5; CB1R; CNR
Species Homo sapiens
Ensembl Gene ENSG00000118432
Encoded Proteins
IDBP-94228
cannabinoid receptor 1 (brain)
IDBP-94230
cannabinoid receptor 1 (brain)
IDBP-94232
cannabinoid receptor 1 (brain)
IDBP-385194
cannabinoid receptor 1 (brain)
IDBP-477038
cannabinoid receptor 1 (brain)
IDBP-595073
cannabinoid receptor 1 (brain)
IDBP-595537
cannabinoid receptor 1 (brain)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes one of two cannabinoid receptors. The cannabinoids, principally delta-9-tetrahydrocannabinol and synthetic analogs, are psychoactive ingredients of marijuana. The cannabinoid receptors are members of the guanine-nucleotide-binding protein (G-protein) coupled receptor family, which inhibit adenylate cyclase activity in a dose-dependent, stereoselective and pertussis toxin-sensitive manner. The two receptors have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. Multiple transcript variants encoding two different protein isoforms have been described for this gene. [provided by RefSeq, May 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:88139864-88166359
Strand Reverse strand
Band q15
Transcripts
ENST00000369501 ENSP00000358513
ENST00000369499 ENSP00000358511
ENST00000362094 ENSP00000355418
ENST00000428600 ENSP00000412192
ENST00000468898 ENSP00000420188
ENST00000549890 ENSP00000446819
ENST00000551417 ENSP00000446702
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 4 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
GO:0004949 cannabinoid receptor activity
GO:0005515 protein binding
GO:0008144 drug binding
Biological Process
GO:0002866 positive regulation of acute inflammatory response to antigenic stimulus
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0007283 spermatogenesis
GO:0007568 aging
GO:0007584 response to nutrient
GO:0007611 learning or memory
GO:0007613 memory
GO:0010976 positive regulation of neuron projection development
GO:0019216 regulation of lipid metabolic process
GO:0019233 sensory perception of pain
GO:0031622 positive regulation of fever generation
GO:0031999 negative regulation of fatty acid beta-oxidation
GO:0032228 regulation of synaptic transmission, GABAergic
GO:0032496 response to lipopolysaccharide
GO:0033004 negative regulation of mast cell activation
GO:0033602 negative regulation of dopamine secretion
GO:0035094 response to nicotine
GO:0042220 response to cocaine
GO:0042593 glucose homeostasis
GO:0043065 positive regulation of apoptotic process
GO:0043271 negative regulation of ion transport
GO:0043278 response to morphine
GO:0045471 response to ethanol
GO:0045759 negative regulation of action potential
GO:0045776 negative regulation of blood pressure
GO:0045777 positive regulation of blood pressure
GO:0050796 regulation of insulin secretion
GO:0051001 negative regulation of nitric-oxide synthase activity
GO:0051966 regulation of synaptic transmission, glutamatergic
GO:0060135 maternal process involved in female pregnancy
GO:0060259 regulation of feeding behavior
GO:0060405 regulation of penile erection
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016021 integral component of membrane
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000044288
View Gene Order
ENSBTAG00000046006
Not yet available
Pathways
NETPATH
REACTOME
REACT_19231
G alpha (i) signalling events pathway
REACT_14828
Class A/1 (Rhodopsin-like receptors) pathway
REACT_14797
Signaling by GPCR pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_21340
GPCR ligand binding pathway
KEGG
hsa04080
Neuroactive ligand-receptor interaction pathway
INOH
PID NCI
ncadherinpathway
N-cadherin signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.75110
RefSeq NM_001160226 NM_001160258 NM_001160259 NM_016083 NM_033181 XM_005248650 XM_006715330
HUGO
OMIM
CCDS CCDS5015 CCDS5016
HPRD 00259
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca