InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CNR1

Summary

InnateDB Protein

IDBP-94228.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CNR1

Protein Name

cannabinoid receptor 1 (brain)

Synonyms

CANN6; CB-R; CB1; CB1A; CB1K5; CB1R; CNR;

Species

Homo sapiens

Ensembl Protein

ENSP00000358513

InnateDB Gene

IDBG-94226 (CNR1)

Protein Structure

UniProt Annotation

Function

Involved in cannabinoid-induced CNS effects. Acts by inhibiting adenylate cyclase. Could be a receptor for anandamide. Inhibits L-type Ca(2+) channel current. Isoform 2 and isoform 3 have altered ligand binding. {ECO:0000269PubMed:15620723}.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Widely expressed. {ECO:0000269PubMed:15620723}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	4 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004949	cannabinoid receptor activity
GO:0005515	protein binding
GO:0008144	drug binding

Biological Process

GO:0002866	positive regulation of acute inflammatory response to antigenic stimulus
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007187	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0007283	spermatogenesis
GO:0007568	aging
GO:0007584	response to nutrient
GO:0007611	learning or memory
GO:0007613	memory
GO:0010976	positive regulation of neuron projection development
GO:0019216	regulation of lipid metabolic process
GO:0019233	sensory perception of pain
GO:0031622	positive regulation of fever generation
GO:0031999	negative regulation of fatty acid beta-oxidation
GO:0032228	regulation of synaptic transmission, GABAergic
GO:0032496	response to lipopolysaccharide
GO:0033004	negative regulation of mast cell activation
GO:0033602	negative regulation of dopamine secretion
GO:0035094	response to nicotine
GO:0042220	response to cocaine
GO:0042593	glucose homeostasis
GO:0043065	positive regulation of apoptotic process
GO:0043271	negative regulation of ion transport
GO:0043278	response to morphine
GO:0045471	response to ethanol
GO:0045759	negative regulation of action potential
GO:0045776	negative regulation of blood pressure
GO:0045777	positive regulation of blood pressure
GO:0050796	regulation of insulin secretion
GO:0051001	negative regulation of nitric-oxide synthase activity
GO:0051966	regulation of synaptic transmission, glutamatergic
GO:0060135	maternal process involved in female pregnancy
GO:0060259	regulation of feeding behavior
GO:0060405	regulation of penile erection

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane
GO:0043231	intracellular membrane-bounded organelle

Protein Structure and Domains

PDB ID

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000810 Cannabinoid receptor type 1
IPR002230 Cannabinoid receptor family
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx
IPR019430 7TM GPCR, serpentine receptor class x (Srx)

PFAM

PF00001
PF10320
PF10328

PRINTS

PR00237
PR00522
PR00362

PIRSF

PIRSF037995

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt