Homo sapiens Gene: FHL5
Summary
InnateDB Gene IDBG-94463.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FHL5
Gene Name four and a half LIM domains 5
Synonyms ACT; dJ393D12.2;
Species Homo sapiens
Ensembl Gene ENSG00000112214
Encoded Proteins
four and a half LIM domains 5
four and a half LIM domains 5
four and a half LIM domains 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is coordinately expressed with activator of cAMP-responsive element modulator (CREM). It is associated with CREM and confers a powerful transcriptional activation function. CREM acts as a transcription factor essential for the differentiation of spermatids into mature spermatozoa. There are multiple polyadenylation sites found in this gene. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Dec 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:96562548-96616636
Strand Forward strand
Band q16.1
Transcripts
ENST00000326771 ENSP00000326022
ENST00000450218 ENSP00000396390
ENST00000541107 ENSP00000442357
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 18 [view]
Protein-Protein 18 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003713 transcription coactivator activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
Biological Process
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
INOH
PID BIOCARTA
Regulation of spermatogenesis by crem [Biocarta view]
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.632608
RefSeq NM_001170807 NM_020482 XM_006715613
HUGO
OMIM
CCDS CCDS5035
HPRD 05497
IMGT
EMBL
GenPept
RNA Seq Atlas