Homo sapiens Gene: GPX2
Summary
InnateDB Gene IDBG-9454.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GPX2
Gene Name glutathione peroxidase 2 (gastrointestinal)
Synonyms GI-GPx; GPRP; GPRP-2; GPx-2; GPx-GI; GSHPx-2; GSHPX-GI;
Species Homo sapiens
Ensembl Gene ENSG00000176153
Encoded Proteins
glutathione peroxidase 2 (gastrointestinal)
glutathione peroxidase 2 (gastrointestinal)
glutathione peroxidase 2 (gastrointestinal)
glutathione peroxidase 2 (gastrointestinal)
glutathione peroxidase 2 (gastrointestinal)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the glutathione peroxidase family and encodes a selenium-dependent glutathione peroxidase that is one of two isoenzymes responsible for the majority of the glutathione-dependent hydrogen peroxide-reducing activity in the epithelium of the gastrointestinal tract. The protein encoded by this locus contains a selenocysteine (Sec) residue encoded by the UGA codon, which normally signals translation termination. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:64939152-64942905
Strand Reverse strand
Band q23.3
Transcripts
ENST00000389614 ENSP00000374265
ENST00000553522 ENSP00000450991
ENST00000557049 ENSP00000451721
ENST00000557323 ENSP00000451844
ENST00000612794 ENSP00000478082
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 3 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004602 glutathione peroxidase activity
GO:0009055 electron carrier activity
Biological Process
GO:0001659 temperature homeostasis
GO:0002862 negative regulation of inflammatory response to antigenic stimulus
GO:0006979 response to oxidative stress
GO:0009609 response to symbiotic bacterium
GO:0051702 interaction with symbiont
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Cellular responses to stress pathway
Metabolism of lipids and lipoproteins pathway
Arachidonic acid metabolism pathway
Detoxification of Reactive Oxygen Species pathway
Synthesis of 12-eicosatetraenoic acid derivatives pathway
Metabolism pathway
Synthesis of 5-eicosatetraenoic acids pathway
Synthesis of 15-eicosatetraenoic acid derivatives pathway
KEGG
Glutathione metabolism pathway
Arachidonic acid metabolism pathway
INOH
PID BIOCARTA
PID NCI
Validated transcriptional targets of deltaNp63 isoforms
Validated transcriptional targets of TAp63 isoforms
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 2877
UniGene Hs.2704
RefSeq NM_002083
HUGO HGNC:4554
OMIM 138319
CCDS CCDS41964
HPRD 11818
IMGT
EMBL
GenPept
RNA Seq Atlas 2877