Version 5.4
Homo sapiens Gene: PREP
Summary
InnateDB Gene IDBG-94804.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PREP
Gene Name prolyl endopeptidase
Synonyms PE; PEP;
Species Homo sapiens
Ensembl Gene ENSG00000085377
Encoded Proteins
IDBP-94806
prolyl endopeptidase
IDBP-385678
prolyl endopeptidase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a cytosolic prolyl endopeptidase that cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long. Prolyl endopeptidases have been reported to be involved in the maturation and degradation of peptide hormones and neuropeptides. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:105277565-105403084
Strand Reverse strand
Band q21
Transcripts
ENST00000369110 ENSP00000358106
ENST00000448705 ENSP00000401796
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
Experimentally validated
Total 12 [view]
Protein-Protein 9 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004252 serine-type endopeptidase activity
GO:0008236 serine-type peptidase activity
GO:0070008 serine-type exopeptidase activity
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
ENSMUSG00000019849
View Gene Order
Ortholuge
SSD Ortholog
Ortholog supports species divergence
ENSBTAG00000016281
Not yet available
Ortholuge
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt P48147
TrEMBL
UniProt Splice Variant
Entrez Gene 5550
UniGene Hs.436564 Hs.611350
RefSeq NM_002726
HUGO HGNC:9358
OMIM 600400
CCDS CCDS5053
HPRD 02673
IMGT
EMBL AL133406 AL139191 AL590871 AY660966 BC030636 CH471051 D21102 X74496
GenPept AAH30636 AAV70495 BAA04661 CAA52605 CAH72545 CAI21416 CAI42689 EAW48426
RNA Seq Atlas 5550

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca