InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PREP

Summary

InnateDB Protein

IDBP-94806.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PREP

Protein Name

prolyl endopeptidase

Synonyms

PE; PEP;

Species

Homo sapiens

Ensembl Protein

ENSP00000358106

InnateDB Gene

IDBG-94804 (PREP)

Protein Structure

UniProt Annotation

Function

Cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long.

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.

Experimentally validated
Total	12 [view]
Protein-Protein	9 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004252	serine-type endopeptidase activity
GO:0008236	serine-type peptidase activity
GO:0070008	serine-type exopeptidase activity

Biological Process

GO:0006508

proteolysis

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001375 Peptidase S9, prolyl oligopeptidase, catalytic domain
IPR002470 Peptidase S9A, prolyl oligopeptidase
IPR023302 Peptidase S9A, N-terminal domain
IPR029058 Alpha/Beta hydrolase fold

PFAM

PF00326
PF02897

PRINTS

PR00862

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P48147