InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: FIG4

Summary

InnateDB Gene

IDBG-95178.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FIG4

Gene Name

FIG4 homolog, SAC1 lipid phosphatase domain containing (S. cerevisiae)

Synonyms

ALS11; BTOP; CMT4J; dJ249I4.1; KIAA0274; SAC3; YVS

Species

Homo sapiens

Ensembl Gene

ENSG00000112367

Encoded Proteins

IDBP-95180

FIG4 homolog, SAC1 lipid phosphatase domain containing (S. cerevisiae)

IDBP-95184

FIG4 homolog, SAC1 lipid phosphatase domain containing (S. cerevisiae)

IDBP-385991

FIG4 homolog, SAC1 lipid phosphatase domain containing (S. cerevisiae)

IDBP-385995

FIG4 homolog, SAC1 lipid phosphatase domain containing (S. cerevisiae)

IDBP-385996

FIG4 homolog, SAC1 lipid phosphatase domain containing (S. cerevisiae)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene belongs to the SAC domain-containing protein gene family. The SAC domain, approximately 400 amino acids in length and consisting of seven conserved motifs, has been shown to possess phosphoinositide phosphatase activity. The yeast homolog, Sac1p, is involved in the regulation of various phosphoinositides, and affects diverse cellular functions such as actin cytoskeleton organization, Golgi function, and maintenance of vacuole morphology. Membrane-bound phosphoinositides function as signaling molecules and play a key role in vesicle trafficking in eukaryotic cells. Mutations in this gene have been associated with Charcot-Marie-Tooth disease, type 4J. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:109691312-109825428

Strand

Forward strand

Band

q21

Transcripts

ENST00000230124	ENSP00000230124
ENST00000368941	ENSP00000357937
ENST00000454215	ENSP00000412156
ENST00000415980	ENSP00000405660
ENST00000419951	ENSP00000396566

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	3 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004438	phosphatidylinositol-3-phosphatase activity
GO:0005515	protein binding
GO:0034593	phosphatidylinositol bisphosphate phosphatase activity
GO:0042578	phosphoric ester hydrolase activity
GO:0043812	phosphatidylinositol-4-phosphate phosphatase activity
GO:0043813	phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity

Biological Process

GO:0006644	phospholipid metabolic process
GO:0006661	phosphatidylinositol biosynthetic process
GO:0007033	vacuole organization
GO:0007626	locomotory behavior
GO:0008152	metabolic process
GO:0008219	cell death
GO:0010976	positive regulation of neuron projection development
GO:0016311	dephosphorylation
GO:0031642	negative regulation of myelination
GO:0032288	myelin assembly
GO:0036092	phosphatidylinositol-3-phosphate biosynthetic process
GO:0043473	pigmentation
GO:0044281	small molecule metabolic process
GO:0046488	phosphatidylinositol metabolic process
GO:0048666	neuron development

Cellular Component

GO:0000139	Golgi membrane
GO:0005783	endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0010008	endosome membrane
GO:0031901	early endosome membrane
GO:0031902	late endosome membrane
GO:0055037	recycling endosome