Homo sapiens Gene: DDO
Summary
InnateDB Gene IDBG-95243.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DDO
Gene Name D-aspartate oxidase
Synonyms DASOX; DDO-1; DDO-2;
Species Homo sapiens
Ensembl Gene ENSG00000203797
Encoded Proteins
D-aspartate oxidase
D-aspartate oxidase
D-aspartate oxidase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a peroxisomal flavoprotein that catalyzes the oxidative deamination of D-aspartate and N-methyl D-aspartate. Flavin adenine dinucleotide or 6-hydroxyflavin adenine dinucleotide can serve as the cofactor in this reaction. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:110391771-110415562
Strand Reverse strand
Band q21
Transcripts
ENST00000368924 ENSP00000357920
ENST00000368923 ENSP00000357919
ENST00000479373 ENSP00000436642
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005515 protein binding
GO:0008445 D-aspartate oxidase activity
GO:0016491 oxidoreductase activity
GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor
GO:0048037 cofactor binding
Biological Process
GO:0006531 aspartate metabolic process
GO:0006533 aspartate catabolic process
GO:0007320 insemination
GO:0007625 grooming behavior
GO:0019478 D-amino acid catabolic process
GO:0042445 hormone metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005777 peroxisome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
Alanine, aspartate and glutamate metabolism pathway
Peroxisome pathway
INOH
Alanine Aspartate Asparagine metabolism pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.195313 Hs.591348
RefSeq NM_003649 NM_004032
HUGO
OMIM
CCDS CCDS5082 CCDS5083
HPRD 00498
IMGT
EMBL
GenPept
RNA Seq Atlas